The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus - Institut de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition Accéder directement au contenu
Article Dans Une Revue Metabolites Année : 2021

The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus

Résumé

Type 2 diabetes mellitus and insulin resistance feature substantial modifications of the lipoprotein profile, including a higher proportion of smaller and denser low-density lipoprotein (LDL) particles. In addition, qualitative changes occur in the composition and structure of LDL, including changes in electrophoretic mobility, enrichment of LDL with triglycerides and ceramides, prolonged retention of modified LDL in plasma, increased uptake by macrophages, and the formation of foam cells. These modifications affect LDL functions and favor an increased risk of cardiovascular disease in diabetic individuals. In this review, we discuss the main findings regarding the structural and functional changes in LDL particles in diabetes pathophysiology and therapeutic strategies targeting LDL in patients with diabetes.
Fichier principal
Vignette du fichier
metabolites-11-00807-v2.pdf (1.68 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-03467601 , version 1 (06-12-2021)

Identifiants

Citer

Isabella Bonilha, Eric Hajduch, Beatriz Luchiari, Wilson Nadruz, Wilfried Le Goff, et al.. The Reciprocal Relationship between LDL Metabolism and Type 2 Diabetes Mellitus. Metabolites, 2021, 11 (12), pp.807. ⟨10.3390/metabo11120807⟩. ⟨hal-03467601⟩
119 Consultations
53 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More