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Actin on and around the Nucleus

Abstract : Actin plays roles in many important cellular processes, including cell motility, organelle movement, and cell signaling. The discovery of transmembrane actin-binding proteins at the outer nuclear membrane (ONM) raises the exciting possibility that actin can play a role in direct force transmission to the nucleus and the genome at its interior. Actin-dependent nucleus displacement was first described a decade ago. We are now gaining a more detailed understanding of its mechanisms, as well as new roles for actin during mitosis and meiosis, for gene expression, and in the cell's response to mechanical stimuli. Here we review these recent developments, the actin-binding proteins involved, the tissue specificity of these mechanisms, and methods developed to reconstitute and study this interaction in vitro.
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Submitted on : Wednesday, March 10, 2021 - 1:20:24 PM
Last modification on : Friday, March 19, 2021 - 11:20:01 AM
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Patricia Davidson, Bruno Cadot. Actin on and around the Nucleus. Trends in Cell Biology, Elsevier, 2021, 31 (3), pp.211 - 223. ⟨10.1016/j.tcb.2020.11.009⟩. ⟨hal-03165074⟩

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