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Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty

Abstract : Tissue-resident memory T cells (T RM) represent a subset of antigen-experienced T cells that are constantly retained in a given tissue with limited traf cking through the circulation. These cells are characterized by expression of molecules enabling their tissue anchoring and downregulation of molecules promoting tissue egress. They reside at sites of previous antigen encounter and their number increases with age. T RM have been shown to provide rapid and ef cient protection against tissue reinfection and T RM density correlates with ef cient antitumor responses. Intriguingly, the density of CD8 T RM is increased in the central nervous system (CNS) of patients with neuroin ammatory diseases such as multiple sclerosis, or suffering from neurodegenerative diseases. In this review, we discuss current knowledge regarding the diversity of CNS-resident CD8 T cells and their role in CNS autoimmunity. Given their likely contribution to the protracted course of several in ammatory diseases of the CNS, their therapeutic targeting becomes an important challenge.
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https://hal.archives-ouvertes.fr/hal-03749081
Contributor : Frédéric Masson Connect in order to contact the contributor
Submitted on : Wednesday, August 10, 2022 - 12:22:34 PM
Last modification on : Friday, September 30, 2022 - 11:26:51 AM

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Doron Merkler, Ilena Vincenti, Frederick Masson, Roland S Liblau. Tissue-resident CD8 T cells in central nervous system inflammatory diseases: present at the crime scene and …guilty. Current Opinion in Immunology, Elsevier, 2022, 77, pp.102211. ⟨10.1016/j.coi.2022.102211⟩. ⟨hal-03749081⟩

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