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Role of superantigenic strains in the prognosis of community-acquired methicillin-susceptible Staphylococcus aureus bacteraemia

Abstract : Methicillin-susceptible Staphylococcus aureus (MSSA) strains can produce superantigenic toxins that may trigger a massive release of pro-inflammatory cytokines, which are involved in the onset of septic shock. This 1-year prospective pilot study assessed the role of the production of superantigenic toxins in the outcome of immunocompetent patients hospitalised for community-acquired MSSA bacteraemia. Thirty-seven patients were enrolled, of whom 14 died in hospital. Fourteen patients had septic shock, and the mortality rate in this subgroup was 56%. Twenty-seven (73%) isolates produced at least one superantigenic toxin, but this did not influence the rate of occurrence of septic shock or death.
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https://hal-unilim.archives-ouvertes.fr/hal-00404659
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Soumis le : jeudi 16 juillet 2009 - 16:32:41
Dernière modification le : mercredi 20 avril 2022 - 03:45:36

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A. Desachy, G. Lina, P. Vignon, A. Hashemzadeh, François Denis, et al.. Role of superantigenic strains in the prognosis of community-acquired methicillin-susceptible Staphylococcus aureus bacteraemia. Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2007, 13 (11), pp.1131-1133. ⟨10.1111/j.1469-0691.2007.01810.x⟩. ⟨hal-00404659⟩

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