Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient

Sébastien Hantz (1, 2) , Detlef Michel (3) , Anne-Marie Fillet (4) , Vincent Guigonis (5) , Gaël Champier (1) , Marie-Christine Mazeron (6) , Albert Bensman , François Denis (1, 2) , Thomas Mertens (3) , Axelle Dehee , Sophie Alain (1, 2)

1 EA3175 - Biologie moléculaire et cellulaire des microorganismes
2 UNILIM - Université de Limoges
3 Institut für Mikrobiologie und Immunologie
4 Service de virologie [CHU Pitié-Salpêtrière]
5 PMRIL - Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations
6 Hôpital Lariboisière

We describe the emergence of a new ganciclovir resistance mutation in the UL97 gene of human cytomegalovirus, deletion of codon 601, after valaciclovir and short-term ganciclovir therapy following kidney transplantation. Its role in ganciclovir resistance was supported by decreased ganciclovir phosphorylation in a recombinant vaccinia virus system.

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Maladies infectieuses; Sciences du Vivant [q-bio]; Microbiologie et Parasitologie; Bactériologie; Sciences du Vivant [q-bio]; Microbiologie et Parasitologie; Virologie

Sébastien Hantz, Detlef Michel, Anne-Marie Fillet, Vincent Guigonis, Gaël Champier, et al.. Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient. Antimicrobial Agents and Chemotherapy, 2005, 49 (4), pp.1580-1583. ⟨10.1128/AAC.49.4.1580-1583.2005⟩. ⟨hal-00405302⟩