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Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient

Abstract : We describe the emergence of a new ganciclovir resistance mutation in the UL97 gene of human cytomegalovirus, deletion of codon 601, after valaciclovir and short-term ganciclovir therapy following kidney transplantation. Its role in ganciclovir resistance was supported by decreased ganciclovir phosphorylation in a recombinant vaccinia virus system.
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https://hal-unilim.archives-ouvertes.fr/hal-00405302
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Soumis le : lundi 20 juillet 2009 - 11:23:22
Dernière modification le : mercredi 19 août 2020 - 11:16:28

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Sébastien Hantz, Detlef Michel, Anne-Marie Fillet, Vincent Guigonis, Gaël Champier, et al.. Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2005, 49 (4), pp.1580-1583. ⟨10.1128/AAC.49.4.1580-1583.2005⟩. ⟨hal-00405302⟩

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