Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient - Université de Limoges Accéder directement au contenu
Article Dans Une Revue Antimicrobial Agents and Chemotherapy Année : 2005

Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient

Résumé

We describe the emergence of a new ganciclovir resistance mutation in the UL97 gene of human cytomegalovirus, deletion of codon 601, after valaciclovir and short-term ganciclovir therapy following kidney transplantation. Its role in ganciclovir resistance was supported by decreased ganciclovir phosphorylation in a recombinant vaccinia virus system.

Dates et versions

hal-00405302 , version 1 (20-07-2009)

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Sébastien Hantz, Detlef Michel, Anne-Marie Fillet, Vincent Guigonis, Gaël Champier, et al.. Early selection of a new UL97 mutant with a severe defect of ganciclovir phosphorylation after valaciclovir prophylaxis and short-term ganciclovir therapy in a renal transplant recipient. Antimicrobial Agents and Chemotherapy, 2005, 49 (4), pp.1580-1583. ⟨10.1128/AAC.49.4.1580-1583.2005⟩. ⟨hal-00405302⟩
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