P75 neurotrophin receptor is sequestered in the Golgi apparatus of the U-87 MG human glioblastoma cell line.

Abstract : The P75 neurotrophin receptor (p75NTR) is a cell surface receptor that can induce apoptosis in many cell types. This receptor plays a major role in the development of the central nervous system and is expressed in some adult brain cells. Its implication in cell apoptosis or survival is probably of major importance in cellular homeostasis and thus p75NTR could be implicated in tumor resistance to death. In this study, we investigated the intracellular expression of p75NTR in a human glioblastoma cell line. Detection of p75NTR receptor in Golgi apparatus by immunofluorescence microscopy, or after Golgi apparatus extraction, could be correlated with a decrease of cell apoptosis leading cells to become tumorous. This hypothesis is supported by a loss of ligand-induced apoptosis in this cell line. Our observations show that p75NTR can be sequestered in the Golgi complex and could then be, in part, responsible for the cell resistance to apoptosis and for brain tumor formation.
Liste complète des métadonnées

Littérature citée [45 références]  Voir  Masquer  Télécharger

https://hal-unilim.archives-ouvertes.fr/hal-00597714
Contributeur : Françoise Merigaud <>
Soumis le : jeudi 31 mai 2018 - 13:55:41
Dernière modification le : mardi 20 août 2019 - 15:30:05
Document(s) archivé(s) le : samedi 1 septembre 2018 - 13:35:58

Fichier

ijo_38_2_391_PDF.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Stéphane Giraud, E. Loum, Barbara Bessette, Muriel Mathonnet, Fabrice Lalloué. P75 neurotrophin receptor is sequestered in the Golgi apparatus of the U-87 MG human glioblastoma cell line.. International Journal of Oncology, Spandidos Publications, 2010, 38 (2), pp.391-399. ⟨10.3892/ijo.2010.862⟩. ⟨hal-00597714⟩

Partager

Métriques

Consultations de la notice

212

Téléchargements de fichiers

288