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X-chromosome lineages and the settlement of the Americas.

Abstract : Most genetic studies on the origins of Native Americans have examined data from mtDNA and Y-chromosome DNA. To complement these studies and to broaden our understanding of the origin of Native American populations, we present an analysis of 1,873 X-chromosomes representing Native American (n = 438) and other continental populations (n = 1,435). We genotyped 36 polymorphic sites, forming an informative haplotype within an 8-kb DNA segment spanning exon 44 of the dystrophin gene. The data reveal continuity from a common Eurasian ancestry between Europeans, Siberians, and Native Americans. However, the loss of two haplotypes frequent in Eurasia (18.8 and 7%) and the rise in frequency of a third haplotype rare elsewhere, indicate a major population bottleneck in the peopling of the Americas. Although genetic drift appears to have played a greater role in the genetic differentiation of Native Americans than in the latitudinally distributed Eurasians, we also observe a signal of a differentiated ancestry of southern and northern populations that cannot be simply explained by the serial southward dilution of genetic diversity. It is possible that the distribution of X-chromosome lineages reflects the genetic structure of the population of Beringia, itself issued from founder effects and a source of subsequent southern colonization(s).
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Soumis le : jeudi 16 juin 2011 - 11:31:17
Dernière modification le : mercredi 19 octobre 2022 - 15:02:06

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Stéphane Bourgeois, Vania Yotova, Sijia Wang, Sylvie Bourthoumieu, Claudia Moreau, et al.. X-chromosome lineages and the settlement of the Americas.. American Journal of Physical Anthropology, 2009, 140 (3), pp.417-28. ⟨10.1002/ajpa.21084⟩. ⟨hal-00600947⟩



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