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The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials.

Abstract : Abstract Effective treatments for amyotrophic lateral sclerosis (ALS) have remained elusive. Only riluzole, a drug thought to affect glutamate metabolism, improves survival albeit to modest extent. Explanations for the negative results of therapeutic trials include a likely heterogeneity, both in disease susceptibility and pathogenic mechanisms, and faulty methodology of clinical trials. Further understanding of these factors will lead to improvements in patient stratification, and in the design of future clinical trials.
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https://hal-unilim.archives-ouvertes.fr/hal-00605454
Contributeur : Elisabeth Grelier <>
Soumis le : vendredi 1 juillet 2011 - 16:08:58
Dernière modification le : lundi 12 mars 2018 - 10:26:02

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Ettore Beghi, Adriano Chiò, Philippe Couratier, Jesùs Esteban, Giancarlo Logroscino, et al.. The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials.. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, Taylor & Francis, 2011, 12 (1), pp.1-10. ⟨10.3109/17482968.2010.502940⟩. ⟨hal-00605454⟩

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