The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials.

Ettore Beghi; Adriano Chiò; Philippe Couratier; Jesùs Esteban; Giancarlo Logroscino; Andrea Millul; Douglas Mitchell; Pierre-Marie Preux; Elisabetta Pupillo; Zorica Stevic; Robert Swingler; Bryan J Traynor; Leonard H van den Berg; Jan H Veldink; Stefano Zoccolella; Benoît Marin

doi:10.3109/17482968.2010.502940

Article dans une revue

The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials.

Ettore Beghi ^{1, *} Adriano Chiò Philippe Couratier ^{2, 3} Jesùs Esteban Giancarlo Logroscino Andrea Millul Douglas Mitchell Pierre-Marie Preux ^{3, 4, 5} Elisabetta Pupillo Zorica Stevic Robert Swingler Bryan J Traynor Leonard H van den Berg Jan H Veldink Stefano Zoccolella Benoît Marin ^{3, 4, 5}

* Auteur correspondant

1 Laboratory of Neurologic Diseases, Mario Negri Institute, Milan

2 Service de Neurologie [CHU Limoges]

3 NETEC - Neuroépidémiologie Tropicale et Comparée

4 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]

5 Laboratoire de Biostatistique et d'Informatique Médicale

Abstract : Abstract Effective treatments for amyotrophic lateral sclerosis (ALS) have remained elusive. Only riluzole, a drug thought to affect glutamate metabolism, improves survival albeit to modest extent. Explanations for the negative results of therapeutic trials include a likely heterogeneity, both in disease susceptibility and pathogenic mechanisms, and faulty methodology of clinical trials. Further understanding of these factors will lead to improvements in patient stratification, and in the design of future clinical trials.

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

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https://hal-unilim.archives-ouvertes.fr/hal-00605454
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Soumis le : vendredi 1 juillet 2011 - 16:08:58
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The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials.

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The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials.

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