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Article Dans Une Revue Expert Review of Neurotherapeutics Année : 2011

Etiologies of epilepsy: a comprehensive review.


Epilepsy is a heterogeneous disorder, the symptoms of which are preventable and controllable to some extent. Significant inter- and intra-country differences in incidence and prevalence exist because multiple etiologic factors are implicated. Many past reviews have addressed sole etiologies. We considered a comprehensive view of all etiologies (genetic/structural/metabolic) to be significant for both the developing and the developed world as well as routine clinical/epidemiology practice. We therefore carried out a comprehensive search for peer-reviewed articles (irrespective of year, region and language; chosen based on novelty and importance) for each etiology. This article was felt to be essential since newer etiologic knowledge has emerged in recent years. Many new genetic links for rarer epilepsy forms have emerged. Epilepsy risk in limbic encephalitis, mechanisms of Alzheimer's-related epilepsy and the genetic basis of cortical malformations have been detailed. An etiological approach to epilepsy in combination with the conventional classification of epilepsy syndromes is required to gain knowledge.
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Dates et versions

hal-00605897 , version 1 (04-07-2011)



Devender Bhalla, Bertrand Godet, Michel Druet-Cabanac, Pierre-Marie Preux. Etiologies of epilepsy: a comprehensive review.. Expert Review of Neurotherapeutics, 2011, 11 (6), pp.861-76. ⟨10.1586/ern.11.51⟩. ⟨hal-00605897⟩
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