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Myenteric plexus alterations downstream from a prenatal intestinal obstruction in a rat model.

Abstract : The enteric nervous system maturation occurs during embryonic life and continues after birth. Some prenatal events on the digestive tract such as intestinal atresia have been shown to dramatically alter this maturation. Thus, we developed a fetal rat model of intestinal atresia by surgically obstructing the small bowel at embryonic day E18. Fetuses were removed at day E21, and small bowels sections were examined by immuno-histochemistry. Synaptophysin and smooth muscle actin staining was used to define the cellular aspect. Labeling revealed marked alterations of the myenteric plexus in the lower extremity of the occluded small bowel. At day E21, the myenteric plexus of the lower part and the 2 muscle layers surrounding it, retained the staining pattern observed at day E17. This cellular pattern was classified as: immature (aspect at day E17) vs. mature (aspect of day E21) by 3 pathologists not familiar with the study. The number of samples with an immature cellular pattern at the lower end of the occluded bowel was different from that observed for the upper end (Mac Nemar test, p<0.008). Our study suggests that a prenatal obstruction induces a maturation delay of the myenteric plexus downstream of the obstruction. This might be important for pediatric purposes.
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Soumis le : vendredi 30 septembre 2011 - 08:44:05
Dernière modification le : dimanche 26 juin 2022 - 13:22:11




Laurent Fourcade, yoanne Mousseau, Francis Jaubert, Franck Sturtz. Myenteric plexus alterations downstream from a prenatal intestinal obstruction in a rat model.. Neuroscience Letters, Elsevier, 2009, 461 (2), pp.126-30. ⟨10.1016/j.neulet.2009.06.009⟩. ⟨hal-00627950⟩



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