Accéder directement au contenu Accéder directement à la navigation
Nouvelle interface
Article dans une revue

Enforced physical inactivity increases endothelial microparticle levels in healthy volunteers.

Abstract : A sedentary lifestyle has adverse effects on the cardiovascular system, including impaired endothelial functions. Subjecting healthy men to 7 days of dry immersion (DI) presented a unique opportunity to analyze the specific effects of enhanced inactivity on the endothelium. We investigated endothelial properties before, during, and after 7 days of DI involving eight subjects. Microcirculatory functions were assessed with laser Doppler in the skin of the calf. We studied basal blood flow and endothelium-dependent and -independent vasodilation. We also measured plasma levels of microparticles, a sign of cellular dysfunction, and soluble endothelial factors, reflecting the endothelial state. Basal flow and endothelium-dependent vasodilation were reduced by DI (22 + or - 4 vs. 15 + or - 2 arbitrary units and 29 + or - 6% vs. 12 + or - 6%, respectively, P < 0.05), and this was accompanied by an increase in circulating endothelial microparticles (EMPs), which was significant on day 3 (42 + or - 8 vs. 65 + or - 10 EMPs/microl, P < 0.05), whereas microparticles from other cell origins remained unchanged. Plasma soluble VEGF decreased significantly during DI, whereas VEGF receptor 1 and soluble CD62E were unchanged, indicating that the increase in EMPs was associated with a change in antiapoptotic tone rather than endothelial activation. Our study showed that extreme physical inactivity in humans induced by 7 days of DI causes microvascular impairment with a disturbance of endothelial functions, associated with a selective increase in EMPs. Microcirculatory endothelial dysfunction might contribute to cardiovascular deconditioning as well as to hypodynamia-associated pathologies. In conclusion, the endothelium should be the focus of special care in situations of acute limitation of physical activity.
Liste complète des métadonnées
Contributeur : Franck Sturtz Connectez-vous pour contacter le contributeur
Soumis le : jeudi 6 octobre 2011 - 16:44:58
Dernière modification le : dimanche 26 juin 2022 - 13:21:55



Nastassia M Navasiolava, Francoise Dignat-George, Florence Sabatier, Irina M Larina, Claire Demiot, et al.. Enforced physical inactivity increases endothelial microparticle levels in healthy volunteers.. AJP - Heart and Circulatory Physiology, 2010, 299 (2), pp.H248-56. ⟨10.1152/ajpheart.00152.2010⟩. ⟨hal-00629846⟩



Consultations de la notice