Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors, Nature Neuroscience, vol.100, issue.7, pp.870-879, 2007. ,
DOI : 10.1038/nn1916
Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons, Neuroscience, vol.100, issue.4, pp.685-688, 2000. ,
DOI : 10.1016/S0306-4522(00)00389-4
Role of the endogenous cannabinoid system in the formalin test of persistent pain in the rat, European Journal of Pharmacology, vol.396, issue.2-3, pp.85-92, 2000. ,
DOI : 10.1016/S0014-2999(00)00226-0
Reassessment of the role of cannabinoids in the management of pain, Current Opinion in Anaesthesiology, vol.20, issue.5, pp.473-477, 2007. ,
DOI : 10.1097/ACO.0b013e3282efd175
Evidence for novel cannabinoid receptors, Pharmacology & Therapeutics, vol.106, issue.2, pp.133-145, 2005. ,
DOI : 10.1016/j.pharmthera.2004.11.005
The endocannabinoid signalling system: Biochemical aspects, Pharmacology Biochemistry and Behavior, vol.81, issue.2, pp.224-238, 2005. ,
DOI : 10.1016/j.pbb.2005.01.027
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol, Chemistry & Biology, vol.14, issue.12, pp.1347-1356, 2007. ,
DOI : 10.1016/j.chembiol.2007.11.006
Control of pain initiation by endogenous cannabinoids, Nature, vol.394, pp.277-281, 1998. ,
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase, Proceedings of the National Academy of Sciences, vol.98, issue.16, pp.9371-9376, 2001. ,
DOI : 10.1073/pnas.161191698
Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves, Am J Physiol, vol.235, pp.97-102, 1978. ,
Targeting the endocannabinoid system: to enhance or reduce?, Nature Reviews Drug Discovery, vol.1761, issue.5, pp.438-455, 2008. ,
DOI : 10.1038/sj.bjp.0706971
Endocannabinoids and the regulation of their levels in health and disease, Current Opinion in Lipidology, vol.18, issue.2, pp.129-140, 2007. ,
DOI : 10.1097/MOL.0b013e32803dbdec
RNA Interference Suggests a Primary Role for Monoacylglycerol Lipase in the Degradation of the Endocannabinoid 2-Arachidonoylglycerol, Molecular Pharmacology, vol.66, issue.5, pp.1260-1264, 2004. ,
DOI : 10.1124/mol.104.002071
Applied Regression Analysis, 1998. ,
DOI : 10.1002/9781118625590
Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide, Mol Pharmacol, vol.57, pp.1045-1050, 2000. ,
Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors, Biochemical Pharmacology, vol.57, issue.4, pp.417-423, 1999. ,
DOI : 10.1016/S0006-2952(98)00314-1
Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain, Neuropharmacology, vol.50, issue.7, pp.814-823, 2006. ,
DOI : 10.1016/j.neuropharm.2005.12.002
receptors, British Journal of Pharmacology, vol.96, issue.6, pp.693-701, 2007. ,
DOI : 10.1038/sj.bjp.0706990
receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain, British Journal of Pharmacology, vol.96, issue.(Suppl 1), pp.319-334, 2008. ,
DOI : 10.1038/sj.bjp.0707531
Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala, European Journal of Neuroscience, vol.280, issue.2, pp.441-458, 2004. ,
DOI : 10.1038/35069076
receptors suppresses the maintenance of inflammatory nociception: a comparative analysis, British Journal of Pharmacology, vol.16, issue.2, pp.153-163, 2007. ,
DOI : 10.1038/sj.bjp.0706984
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia, Pain, vol.32, issue.1, pp.77-88, 1988. ,
DOI : 10.1016/0304-3959(88)90026-7
An endocannabinoid mechanism for stress-induced analgesia, Nature, vol.435, issue.7045, pp.1108-1112, 2005. ,
DOI : 10.1038/nature03658
CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids, Proceedings of the National Academy of Sciences, vol.102, issue.8, pp.3093-3098, 2005. ,
DOI : 10.1073/pnas.0409888102
CB2 cannabinoid receptor mediation of antinociception, Pain, vol.122, issue.1, pp.36-42, 2006. ,
DOI : 10.1016/j.pain.2005.12.018
Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models, British Journal of Pharmacology, vol.304, issue.3, pp.281-288, 2006. ,
DOI : 10.1038/sj.bjp.0706510
Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain, British Journal of Pharmacology, vol.283, issue.69, pp.624-632, 2007. ,
DOI : 10.1038/sj.bjp.0707433
Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain, Journal of Neuroscience, vol.26, issue.51, pp.13318-13327, 2006. ,
DOI : 10.1523/JNEUROSCI.3326-06.2006
Modulation of anxiety through blockade of anandamide hydrolysis, Nature Medicine, vol.121, issue.1, pp.76-81, 2003. ,
DOI : 10.1016/0028-3908(87)90230-9
URB602 Inhibits Monoacylglycerol Lipase and??Selectively Blocks 2-Arachidonoylglycerol Degradation in Intact Brain Slices, Chemistry & Biology, vol.14, issue.12, pp.1357-1365, 2007. ,
DOI : 10.1016/j.chembiol.2007.10.017
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB1 Receptor Knockout Mice, Science, vol.283, issue.5400, pp.401-404, 1999. ,
DOI : 10.1126/science.283.5400.401
Cannabinoids and Pain, Handb Exp Pharmacol, vol.177, pp.265-306, 2007. ,
DOI : 10.1007/978-3-540-33823-9_10
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum, Nature Neuroscience, vol.294, issue.2, pp.152-159, 2008. ,
DOI : 10.1038/nn2042
CB2 cannabinoid receptor-mediated peripheral antinociception, Pain, vol.93, issue.3, pp.239-245, 2001. ,
DOI : 10.1016/S0304-3959(01)00321-9
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochemical Pharmacology, vol.50, issue.1, pp.83-90, 1995. ,
DOI : 10.1016/0006-2952(95)00109-D
Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain, Pain, vol.126, issue.1, pp.102-114, 2006. ,
DOI : 10.1016/j.pain.2006.06.016
Identification of a Novel Endocannabinoid-Hydrolyzing Enzyme Expressed by Microglial Cells, Journal of Neuroscience, vol.27, issue.11, pp.2883-2889, 2007. ,
DOI : 10.1523/JNEUROSCI.4830-06.2007
Evidence for the Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2-Arachidonoylglycerol in 12-O-Tetradecanoylphorbol-13-acetate-induced Acute Inflammation in Mouse Ear, Journal of Biological Chemistry, vol.280, issue.18, pp.18488-18497, 2005. ,
DOI : 10.1074/jbc.M413260200
The pharmacology of cannabinoid receptors and their ligands: an overview, International Journal of Obesity, vol.353, pp.13-18, 2006. ,
DOI : 10.1124/mol.105.016162
Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats, Neuropharmacology, vol.52, issue.2, pp.415-422, 2007. ,
DOI : 10.1016/j.neuropharm.2006.08.011
A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury, Pain, vol.43, issue.2, pp.205-218, 1990. ,
DOI : 10.1016/0304-3959(90)91074-S
Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats, Neuropharmacology, vol.45, issue.3, pp.404-411, 2003. ,
DOI : 10.1016/S0028-3908(03)00195-3
2-Arachidonoylglycerol and the cannabinoid receptors, Chemistry and Physics of Lipids, vol.108, issue.1-2, pp.89-106, 2000. ,
DOI : 10.1016/S0009-3084(00)00189-4
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia, Neuropharmacology, vol.50, issue.3, pp.372-379, 2006. ,
DOI : 10.1016/j.neuropharm.2005.10.007
Therapeutic Potential of Endocannabinoid-Hydrolysing Enzyme Inhibitors, Basic & Clinical Pharmacology & Toxicology, vol.90, issue.5, pp.287-293, 2007. ,
DOI : 10.1111/j.1527-3458.2006.00021.x
Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve, Pain, vol.57, issue.3, pp.375-382, 1994. ,
DOI : 10.1016/0304-3959(94)90013-2
pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain, Neuroscience, vol.132, pp.1093-1102 ,
Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes, Journal of Neuroscience Research, vol.173, issue.7, pp.1310-1322, 2006. ,
DOI : 10.1002/jnr.20821
Cannabinoid Mechanisms of Pain Suppression, Handb Exp Pharmacol, vol.168, pp.509-554, 2005. ,
DOI : 10.1007/3-540-26573-2_17
Cannabinoids and neuroinflammation, British Journal of Pharmacology, vol.65, issue.5, pp.775-785, 2004. ,
DOI : 10.1038/sj.bjp.0705667
Statistical Principles in Experimental Design, 1971. ,
DOI : 10.1037/11774-000
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice, Proceedings of the National Academy of Sciences, vol.96, issue.10, pp.5780-5785, 1999. ,
DOI : 10.1073/pnas.96.10.5780