N. Agarwal, P. Pacher, I. Tegeder, F. Amaya, C. Constantin et al., Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors, Nature Neuroscience, vol.100, issue.7, pp.870-879, 2007.
DOI : 10.1038/nn1916

J. Ahluwalia, L. Urban, M. Capogna, S. Bevan, and I. Nagy, Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons, Neuroscience, vol.100, issue.4, pp.685-688, 2000.
DOI : 10.1016/S0306-4522(00)00389-4

P. Beaulieu, T. Bisogno, S. Punwar, W. Farquhar-smith, G. Ambrosino et al., Role of the endogenous cannabinoid system in the formalin test of persistent pain in the rat, European Journal of Pharmacology, vol.396, issue.2-3, pp.85-92, 2000.
DOI : 10.1016/S0014-2999(00)00226-0

P. Beaulieu and M. Ware, Reassessment of the role of cannabinoids in the management of pain, Current Opinion in Anaesthesiology, vol.20, issue.5, pp.473-477, 2007.
DOI : 10.1097/ACO.0b013e3282efd175

M. Begg, P. Pacher, S. Batkai, D. Osei-hyiaman, L. Offertaler et al., Evidence for novel cannabinoid receptors, Pharmacology & Therapeutics, vol.106, issue.2, pp.133-145, 2005.
DOI : 10.1016/j.pharmthera.2004.11.005

T. Bisogno, A. Ligresti, D. Marzo, and V. , The endocannabinoid signalling system: Biochemical aspects, Pharmacology Biochemistry and Behavior, vol.81, issue.2, pp.224-238, 2005.
DOI : 10.1016/j.pbb.2005.01.027

J. Blankman, G. Simon, and B. Cravatt, A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol, Chemistry & Biology, vol.14, issue.12, pp.1347-1356, 2007.
DOI : 10.1016/j.chembiol.2007.11.006

A. Calignano, L. Rana, G. Giuffrida, A. Piomelli, and D. , Control of pain initiation by endogenous cannabinoids, Nature, vol.394, pp.277-281, 1998.

B. Cravatt, K. Demarest, M. Patricelli, M. Bracey, D. Giang et al., Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase, Proceedings of the National Academy of Sciences, vol.98, issue.16, pp.9371-9376, 2001.
DOI : 10.1073/pnas.161191698

A. De-léan, P. Munson, and D. Rodbard, Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves, Am J Physiol, vol.235, pp.97-102, 1978.

D. Marzo and V. , Targeting the endocannabinoid system: to enhance or reduce?, Nature Reviews Drug Discovery, vol.1761, issue.5, pp.438-455, 2008.
DOI : 10.1038/sj.bjp.0706971

D. Marzo, V. Petrosino, and S. , Endocannabinoids and the regulation of their levels in health and disease, Current Opinion in Lipidology, vol.18, issue.2, pp.129-140, 2007.
DOI : 10.1097/MOL.0b013e32803dbdec

T. Dinh, S. Kathuria, and D. Piomelli, RNA Interference Suggests a Primary Role for Monoacylglycerol Lipase in the Degradation of the Endocannabinoid 2-Arachidonoylglycerol, Molecular Pharmacology, vol.66, issue.5, pp.1260-1264, 2004.
DOI : 10.1124/mol.104.002071

N. Draper and H. Smith, Applied Regression Analysis, 1998.
DOI : 10.1002/9781118625590

W. Gonsiorek, C. Lunn, X. Fan, S. Narula, D. Lundell et al., Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide, Mol Pharmacol, vol.57, pp.1045-1050, 2000.

S. Goparaju, N. Ueda, K. Taniguchi, and S. Yamamoto, Enzymes of porcine brain hydrolyzing 2-arachidonoylglycerol, an endogenous ligand of cannabinoid receptors, Biochemical Pharmacology, vol.57, issue.4, pp.417-423, 1999.
DOI : 10.1016/S0006-2952(98)00314-1

J. Guindon and P. Beaulieu, Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain, Neuropharmacology, vol.50, issue.7, pp.814-823, 2006.
DOI : 10.1016/j.neuropharm.2005.12.002

J. Guindon, J. Desroches, and P. Beaulieu, receptors, British Journal of Pharmacology, vol.96, issue.6, pp.693-701, 2007.
DOI : 10.1038/sj.bjp.0706990

J. Guindon and A. Hohmann, receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain, British Journal of Pharmacology, vol.96, issue.(Suppl 1), pp.319-334, 2008.
DOI : 10.1038/sj.bjp.0707531

A. Gulyas, B. Cravatt, M. Bracey, T. Dinh, D. Piomelli et al., Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala, European Journal of Neuroscience, vol.280, issue.2, pp.441-458, 2004.
DOI : 10.1038/35069076

T. Gutierrez, J. Farthing, A. Zvonok, A. Makriyannis, and A. Hohmann, receptors suppresses the maintenance of inflammatory nociception: a comparative analysis, British Journal of Pharmacology, vol.16, issue.2, pp.153-163, 2007.
DOI : 10.1038/sj.bjp.0706984

K. Hargreaves, R. Dubner, F. Brown, C. Flores, and J. Joris, A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia, Pain, vol.32, issue.1, pp.77-88, 1988.
DOI : 10.1016/0304-3959(88)90026-7

A. Hohmann, R. Suplita, N. Bolton, M. Neely, D. Fegley et al., An endocannabinoid mechanism for stress-induced analgesia, Nature, vol.435, issue.7045, pp.1108-1112, 2005.
DOI : 10.1038/nature03658

M. Ibrahim, F. Porreca, J. Lai, P. Albrecht, F. Rice et al., CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids, Proceedings of the National Academy of Sciences, vol.102, issue.8, pp.3093-3098, 2005.
DOI : 10.1073/pnas.0409888102

M. Ibrahim, M. Rude, N. Stagg, H. Mata, J. Lai et al., CB2 cannabinoid receptor mediation of antinociception, Pain, vol.122, issue.1, pp.36-42, 2006.
DOI : 10.1016/j.pain.2005.12.018

A. Jayamanne, R. Greenwood, V. Mitchell, S. Aslan, D. Piomelli et al., Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models, British Journal of Pharmacology, vol.304, issue.3, pp.281-288, 2006.
DOI : 10.1038/sj.bjp.0706510

M. Jhaveri, D. Richardson, and V. Chapman, Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain, British Journal of Pharmacology, vol.283, issue.69, pp.624-632, 2007.
DOI : 10.1038/sj.bjp.0707433

M. Jhaveri, D. Richardson, D. Kendall, D. Barrett, and V. Chapman, Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain, Journal of Neuroscience, vol.26, issue.51, pp.13318-13327, 2006.
DOI : 10.1523/JNEUROSCI.3326-06.2006

S. Kathuria, S. Gaetani, D. Fegley, F. Valiño, A. Duranti et al., Modulation of anxiety through blockade of anandamide hydrolysis, Nature Medicine, vol.121, issue.1, pp.76-81, 2003.
DOI : 10.1016/0028-3908(87)90230-9

A. King, A. Duranti, A. Tontini, S. Rivara, A. Rosengarth et al., URB602 Inhibits Monoacylglycerol Lipase and??Selectively Blocks 2-Arachidonoylglycerol Degradation in Intact Brain Slices, Chemistry & Biology, vol.14, issue.12, pp.1357-1365, 2007.
DOI : 10.1016/j.chembiol.2007.10.017

C. Ledent, O. Valverde, G. Cossu, F. Petitet, J. Aubert et al., Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB1 Receptor Knockout Mice, Science, vol.283, issue.5400, pp.401-404, 1999.
DOI : 10.1126/science.283.5400.401

I. Lever and A. Rice, Cannabinoids and Pain, Handb Exp Pharmacol, vol.177, pp.265-306, 2007.
DOI : 10.1007/978-3-540-33823-9_10

M. Maccarrone, S. Rossi, M. Bari, D. Chiara, V. Fezza et al., Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum, Nature Neuroscience, vol.294, issue.2, pp.152-159, 2008.
DOI : 10.1038/nn2042

T. Malan, M. Ibrahim, H. Deng, Q. Liu, H. Mata et al., CB2 cannabinoid receptor-mediated peripheral antinociception, Pain, vol.93, issue.3, pp.239-245, 2001.
DOI : 10.1016/S0304-3959(01)00321-9

R. Mechoulam, S. Ben-shabat, L. Hanus, M. Ligumsky, N. Kaminski et al., Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochemical Pharmacology, vol.50, issue.1, pp.83-90, 1995.
DOI : 10.1016/0006-2952(95)00109-D

S. Mitrirattanakul, N. Ramakul, A. Guerrero, Y. Matsuka, T. Ono et al., Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain, Pain, vol.126, issue.1, pp.102-114, 2006.
DOI : 10.1016/j.pain.2006.06.016

G. Muccioli, C. Xu, E. Odah, E. Cudaback, J. Cisneros et al., Identification of a Novel Endocannabinoid-Hydrolyzing Enzyme Expressed by Microglial Cells, Journal of Neuroscience, vol.27, issue.11, pp.2883-2889, 2007.
DOI : 10.1523/JNEUROSCI.4830-06.2007

S. Oka, S. Yanagimoto, S. Ikeda, M. Gokoh, S. Kishimoto et al., Evidence for the Involvement of the Cannabinoid CB2 Receptor and Its Endogenous Ligand 2-Arachidonoylglycerol in 12-O-Tetradecanoylphorbol-13-acetate-induced Acute Inflammation in Mouse Ear, Journal of Biological Chemistry, vol.280, issue.18, pp.18488-18497, 2005.
DOI : 10.1074/jbc.M413260200

R. Pertwee, The pharmacology of cannabinoid receptors and their ligands: an overview, International Journal of Obesity, vol.353, pp.13-18, 2006.
DOI : 10.1124/mol.105.016162

S. Petrosino, E. Palazzo, V. De-novellis, T. Bisogno, F. Rossi et al., Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats, Neuropharmacology, vol.52, issue.2, pp.415-422, 2007.
DOI : 10.1016/j.neuropharm.2006.08.011

Z. Seltzer, R. Dubner, and Y. Shir, A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury, Pain, vol.43, issue.2, pp.205-218, 1990.
DOI : 10.1016/0304-3959(90)91074-S

D. Sokal, S. Elmes, D. Kendall, and V. Chapman, Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats, Neuropharmacology, vol.45, issue.3, pp.404-411, 2003.
DOI : 10.1016/S0028-3908(03)00195-3

T. Sugiura and K. Waku, 2-Arachidonoylglycerol and the cannabinoid receptors, Chemistry and Physics of Lipids, vol.108, issue.1-2, pp.89-106, 2000.
DOI : 10.1016/S0009-3084(00)00189-4

R. Suplita, T. Gutierrez, D. Fegley, D. Piomelli, and A. Hohmann, Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia, Neuropharmacology, vol.50, issue.3, pp.372-379, 2006.
DOI : 10.1016/j.neuropharm.2005.10.007

S. Saario and J. Laitinen, Therapeutic Potential of Endocannabinoid-Hydrolysing Enzyme Inhibitors, Basic & Clinical Pharmacology & Toxicology, vol.90, issue.5, pp.287-293, 2007.
DOI : 10.1111/j.1527-3458.2006.00021.x

M. Tal and G. Bennett, Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve, Pain, vol.57, issue.3, pp.375-382, 1994.
DOI : 10.1016/0304-3959(94)90013-2

. Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain, Neuroscience, vol.132, pp.1093-1102

J. Walczak, V. Pichette, F. Leblond, K. Desbiens, and P. Beaulieu, Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes, Journal of Neuroscience Research, vol.173, issue.7, pp.1310-1322, 2006.
DOI : 10.1002/jnr.20821

J. Walker and A. Hohmann, Cannabinoid Mechanisms of Pain Suppression, Handb Exp Pharmacol, vol.168, pp.509-554, 2005.
DOI : 10.1007/3-540-26573-2_17

L. Walter and N. Stella, Cannabinoids and neuroinflammation, British Journal of Pharmacology, vol.65, issue.5, pp.775-785, 2004.
DOI : 10.1038/sj.bjp.0705667

B. Winer, Statistical Principles in Experimental Design, 1971.
DOI : 10.1037/11774-000

A. Zimmer, A. Zimmer, A. Hohmann, M. Herkenham, and T. Bonner, Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice, Proceedings of the National Academy of Sciences, vol.96, issue.10, pp.5780-5785, 1999.
DOI : 10.1073/pnas.96.10.5780