Glycosyl bis-porphyrin conjugates: synthesis and potential application in PDT.

Vincent Sol (1) , Vincent Chaleix (1) , Yves Champavier (2) , Robert Granet (1) , Y.M. Huang , Pierre Krausz (1)

1 LCSN - Laboratoire de Chimie des Substances Naturelles
2 RMN - Service Commun de Résonance Magnétique Nucléaire

Syntheses of new glycosylated neutral and cationic porphyrin dimers linked at the meso-position via a flexible hydrocarbon chain are described. A detailed 1H and 13C NMR study allows their complete structural elucidation. The UV-visible, fluorescence and MALDI mass spectra are also presented. Photocytotoxicities of these compounds against K562 leukaemia cell line are compared to those of Photofrin II.

Mots clés: Photodynamic therapy; Sugar; Cationic porphyrins; Glycosylated porphyrins; Dimers

Domaines: Chimie organique

Vincent Sol, Vincent Chaleix, Yves Champavier, Robert Granet, Y.M. Huang, et al.. Glycosyl bis-porphyrin conjugates: synthesis and potential application in PDT.. Bioorganic and Medicinal Chemistry, 2006, 14 (23), pp.7745-7760. ⟨10.1016/j.bmc.2006.08.004⟩. ⟨hal-00684103⟩