Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Bioactive capsular polysaccharide from the thermophilic cyanophyte/cyanobacterium Mastigocladus laminosus - cytotoxic properties.

Abstract : The capsular polysaccharide produced by the thermophilic blue green alga/cyanobacterium Mastigocladus laminosus was tested for its cytotoxic activity against the A431 human epidermoid carcinoma cell line. This polysaccharide inhibited the proliferation of A431 cells in a dose-dependent manner with an IC (50) value of 50 microg mL (-1). In addition, this polysaccharide strongly inhibited A431 cell migration and invasion. Preliminary experiments showing that secretion of metalloproteinases MMP2 and MMP9 by A431 tumour cells was inhibited by this polysaccharide suggest that this mechanism of action could play a role in its anti-migration and anti-invasive properties. Acid hydrolysis of the polysaccharide produced specific oligosaccharides which conserved - at similar concentrations - their cytotoxic, anti-migration and anti-invasion properties; in this case, the mechanism of action was nevertheless uncorrelated to the decrease of metalloproteinase expression.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-00685459
Contributeur : Françoise Merigaud <>
Soumis le : jeudi 5 avril 2012 - 10:54:11
Dernière modification le : mardi 20 mars 2018 - 16:36:32

Identifiants

Collections

Citation

Vincent Gloaguen, Henri Morvan, Lucien Hoffmann, Odile Sainte Catherine, Michel Kraemer, et al.. Bioactive capsular polysaccharide from the thermophilic cyanophyte/cyanobacterium Mastigocladus laminosus - cytotoxic properties.. Planta Medica, Georg Thieme Verlag, 2007, 73 (13), pp.1402-1406. ⟨10.1055/s-2007-990237⟩. ⟨hal-00685459⟩

Partager

Métriques

Consultations de la notice

206