Synthesis and antiviral evaluation of AZT analogues with A spacer arm between glucidic and base moieties. Part II.

Vincent Roy (1) , Rachida Zerrouki (1) , Pierre Krausz (1) , Géraldine Laumond , Anne-Marie Aubertin

1 LCSN - Laboratoire de Chimie des Substances Naturelles

This article describes the synthesis of a series of AZT analogues bearing an acyclic chain between the sugar and the base moieties is described. These new compounds were readily obtained using microwave irradiation. The compounds were characterized by (1)H NMR and IR spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.

Domaines: Chimie organique

Vincent Roy, Rachida Zerrouki, Pierre Krausz, Géraldine Laumond, Anne-Marie Aubertin. Synthesis and antiviral evaluation of AZT analogues with A spacer arm between glucidic and base moieties. Part II.. Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 (5), pp.413-421. ⟨10.1080/15257770701426153⟩. ⟨hal-00685483⟩