Synthesis and cellular uptake of superparamagnetic dextran-nanoparticles with porphyrinic motifs grafted by esterification

Romain Lucas (1) , Robert Granet (1) , Vincent Sol (1) , Caroline Le Morvan (1) , Clotilde Policar (2, 3) , Eric Riviere (2) , Pierre Krausz (1)

1 LCSN - Laboratoire de Chimie des Substances Naturelles
2 ICMMO - Institut de Chimie Moléculaire et des Matériaux d'Orsay
3 UPMC - Université Pierre et Marie Curie - Paris 6

This paper describes new superparamagnetic nanoparticles bearing dextran-grafted porphyrins with effective cellular uptake properties. They average 110 nm in diameter and are composed of a 5 nm iron oxide core coated with protoporphyrin grafted dextrans. These particles show good magnetic properties, are avidly incorporated into cultured cancer cell lines, and thus present a great potential for cellular imaging and photodynamic therapy applications.

Domaines: Chimie organique

Romain Lucas, Robert Granet, Vincent Sol, Caroline Le Morvan, Clotilde Policar, et al.. Synthesis and cellular uptake of superparamagnetic dextran-nanoparticles with porphyrinic motifs grafted by esterification. e-polymers, 2007, 089, pp.089. ⟨hal-00685825⟩