Efficient Synthesis of "Star-like" Surfactants via "Click Chemistry" [3+2] Copper (I)-catalyzed Cycloaddition

Virginie Neto (1) , Robert Granet (1) , Pierre Krausz (1) , Grahame Mackenzie

1 LCSN - Laboratoire de Chimie des Substances Naturelles

We report an efficient synthesis of tetra‐ and hexa‐substituted carbohydrate‐coated compounds, which we have named "star‐like" surfactants, starting from either α‐methylglucose or myo‐inositol as a central core. The synthesis explores a new approach to such multipolar compounds using [3+2] copper (I)‐catalyzed cycloadditions to attach the respective building blocks.

Mots clés: Click chemistry; Surfactant; Carbohydrate; "Click chemistry"

Domaines: Chimie organique

Virginie Neto, Robert Granet, Pierre Krausz, Grahame Mackenzie. Efficient Synthesis of "Star-like" Surfactants via "Click Chemistry" [3+2] Copper (I)-catalyzed Cycloaddition. Journal of Carbohydrate Chemistry, 2008, 27 (4), pp.231-237. ⟨10.1080/07328300802105365⟩. ⟨hal-00686426⟩