A rapid efficient microwave-assisted synthesis of a 3',5'-pentathymidine by copper(I)-catalyzed [3+2] cycloaddition. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Tetrahedron Année : 2008

A rapid efficient microwave-assisted synthesis of a 3',5'-pentathymidine by copper(I)-catalyzed [3+2] cycloaddition.

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Résumé

Starting from 5?-O-tosylthymidine, sequential azidation and Cu-catalyzed [3+2] azide?alkyne 1,3-dipolar cycloaddition led to the formation of a 3?,5?-pentathymidine in high yield. The whole process needed only work-up/precipitation steps and was completed within just 18min, thanks to microwave activation.

Dates et versions

hal-00686723 , version 1 (11-04-2012)

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Citer

Romain Lucas, Rachida Zerrouki, Robert Granet, Pierre Krausz, Yves Champavier. A rapid efficient microwave-assisted synthesis of a 3',5'-pentathymidine by copper(I)-catalyzed [3+2] cycloaddition.. Tetrahedron, 2008, 64 (23), pp.5467-5471. ⟨10.1016/j.tet.2008.04.006⟩. ⟨hal-00686723⟩
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