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Article dans une revue

Microwave-assisted synthesis of a triazole-linked 3'-5' dithymidine using click chemistry.

Abstract : Synthesis of a triazole-linked 3'-5' thymidine dimer making use of 1,3-dipolar cycloaddition is described. The azido-precursor was obtained by regioselective chlorination of thymidine, followed by azidation. The second precursor, a propargyl derivative, was obtained by selective 3'-O-alkylation of thymidine. Two 'click systems' were compared to obtain the desired dimer. These reactions were performed by microwave irradiation.
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https://hal-unilim.archives-ouvertes.fr/hal-00686734
Contributeur : Françoise Merigaud <>
Soumis le : mercredi 11 avril 2012 - 10:28:09
Dernière modification le : mardi 20 mars 2018 - 16:36:42

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  • HAL Id : hal-00686734, version 1

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Romain Lucas, Virginie Neto, Amel Hadj-Bouazza, Rachida Zerrouki, Robert Granet, et al.. Microwave-assisted synthesis of a triazole-linked 3'-5' dithymidine using click chemistry.. Tetrahedron Letters, Elsevier, 2008, 49 (6), pp.1004-1007. ⟨hal-00686734⟩

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