An efficient route to dimeric porphyrin-RGD peptide conjugates via olefin metathesis.

Vincent Sol (1) , Vincent Chaleix (1) , Robert Granet (1) , Pierre Krausz (1)

1 LCSN - Laboratoire de Chimie des Substances Naturelles

We report the efficient use of cross-metathesis for the solid-phase synthesis of a porphyrin dimer containing as a spacer a pentapeptide moiety with RGD sequence. Such compound appears as a promising candidate for application in PDT.

Domaines: Chimie; Chimie organique

Vincent Sol, Vincent Chaleix, Robert Granet, Pierre Krausz. An efficient route to dimeric porphyrin-RGD peptide conjugates via olefin metathesis.. Tetrahedron, 2008, 14 (2), pp.364-371. ⟨10.1016/j.tet.2007.10.092⟩. ⟨hal-00686740⟩