Synthesis and biological activity of chloroethyl pyrimidine nucleosides.

Ludovic Colombeau (1) , Karine Teste (1) , Amel Hadj-Bouazza (1) , Vincent Chaleix (1) , Rachida Zerrouki (1) , Michel Kraemer , Odile Sainte-Catherine

1 LCSN - Laboratoire de Chimie des Substances Naturelles

The synthesis and biological activity of chloroethyl pyrimidine nucleosides is presented. One of these new nucleosides analogues significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.

Mots clés: Nucleoside analogue; microwave activation; chloroethylnucleoside; anticancer; anti-migration; anti-invasion

Domaines: Chimie; Chimie organique

Ludovic Colombeau, Karine Teste, Amel Hadj-Bouazza, Vincent Chaleix, Rachida Zerrouki, et al.. Synthesis and biological activity of chloroethyl pyrimidine nucleosides.. Nucleosides, Nucleotides and Nucleic Acids, 2008, 27 (2), pp.110-20. ⟨10.1080/15257770701795813⟩. ⟨hal-00686793⟩