Synthesis and biological activity of mustard derivatives of thymine.

Amel Hadj-Bouazza; Karine Teste; Rachida Zerrouki; Ludovic Colombeau; Odile Sainte-Catherine; Vincent Chaleix; Michel Kraemer

doi:10.1080/15257770802086872

Article dans une revue

Synthesis and biological activity of mustard derivatives of thymine.

Amel Hadj-Bouazza ¹ Karine Teste ¹ Rachida Zerrouki ¹ Ludovic Colombeau ¹ Odile Sainte-Catherine Vincent Chaleix ¹ Michel Kraemer ²

1 LCSN - Laboratoire de Chimie des Substances Naturelles

2 Schiller Médical SA

Abstract : The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.

Keywords : Nitrogen mustards DNA-cross-linking anticancer thymine microwave

Type de document :

Article dans une revue

Domaine :

Chimie / Chimie organique

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https://hal-unilim.archives-ouvertes.fr/hal-00687051
Contributeur : Françoise Merigaud <>
Soumis le : jeudi 12 avril 2012 - 09:50:33
Dernière modification le : mardi 20 mars 2018 - 16:36:31

Synthesis and biological activity of mustard derivatives of thymine.

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