Synthesis and biological activity of mustard derivatives of thymine.

Amel Hadj-Bouazza (1) , Karine Teste (1) , Rachida Zerrouki (1) , Ludovic Colombeau (1) , Odile Sainte-Catherine , Vincent Chaleix (1) , Michel Kraemer (2)

1 LCSN - Laboratoire de Chimie des Substances Naturelles
2 Schiller Médical SA

The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line.

Mots clés: Nitrogen mustards; DNA-cross-linking; anticancer; thymine; microwave

Domaines: Chimie organique

Amel Hadj-Bouazza, Karine Teste, Rachida Zerrouki, Ludovic Colombeau, Odile Sainte-Catherine, et al.. Synthesis and biological activity of mustard derivatives of thymine.. Nucleosides, Nucleotides and Nucleic Acids, 2008, 27 (5), pp.439-48. ⟨10.1080/15257770802086872⟩. ⟨hal-00687051⟩