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Article dans une revue
Photodynamic effects of porphyrin-polyamine conjugates in human breast cancer and keratinocyte cell lines.
Abstract : Porphyrin-polyamine conjugates bearing two (cis or trans position) or four spermidine or spermine units were synthesized. We studied the photostability, the hydrophilic/lipophilic balance of porphyrin-polyamine derivatives and the production of singlet oxygen. All these compounds possess physicochemical features required for their use in PDT. Then, we investigated the photocytotoxic efficacy of these porphyrin-polyamine derivatives and the cell death pathway implicated. All compounds appear to be more efficient than Photofrin® to induce HaCat and MCF7 cell death, essentially by apoptosis. Collectively, these data show that porphyrin-polyamine conjugates could be promising phototherapeutic agents.
https://hal-unilim.archives-ouvertes.fr/hal-00688708
Contributeur : Claire Douady Connectez-vous pour contacter le contributeur
Soumis le : mercredi 18 avril 2012 - 12:14:00
Dernière modification le : mercredi 20 octobre 2021 - 01:31:03
Contributeur : Claire Douady Connectez-vous pour contacter le contributeur
Soumis le : mercredi 18 avril 2012 - 12:14:00
Dernière modification le : mercredi 20 octobre 2021 - 01:31:03
