3-Substituted pyrazinone nucleosides--a new family of D4T analogues.

Nathalie Batoux , Robert Granet (1) , Rachida Zerrouki (1) , Pierre Krausz (1)

1 LCSN - Laboratoire de Chimie des Substances Naturelles

The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by (1)H NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.

Domaines: Chimie organique

Nathalie Batoux, Robert Granet, Rachida Zerrouki, Pierre Krausz. 3-Substituted pyrazinone nucleosides--a new family of D4T analogues.. Nucleosides, Nucleotides and Nucleic Acids, 2009, 28 (9), pp.866-873. ⟨10.1080/15257770903169999⟩. ⟨hal-00696080⟩