3-Substituted pyrazinone nucleosides--a new family of D4T analogues.

Nathalie Batoux; Robert Granet; Rachida Zerrouki; Pierre Krausz

doi:10.1080/15257770903169999

Article dans une revue

3-Substituted pyrazinone nucleosides--a new family of D4T analogues.

Nathalie Batoux Robert Granet ¹ Rachida Zerrouki ¹ Pierre Krausz ¹

1 LCSN - Laboratoire de Chimie des Substances Naturelles

Abstract : The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by (1)H NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.

Type de document :

Article dans une revue

Domaine :

Chimie / Chimie organique

Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-00696080
Contributeur : Claire Douady Connectez-vous pour contacter le contributeur
Soumis le : jeudi 10 mai 2012 - 16:50:10
Dernière modification le : mercredi 20 octobre 2021 - 01:31:03

3-Substituted pyrazinone nucleosides--a new family of D4T analogues.

Identifiants

Collections

Citation

Exporter

Métriques

3-Substituted pyrazinone nucleosides--a new family of D4T analogues.

Identifiants

Collections

Citation

Exporter

Partager

Métriques