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Article dans une revue

3-Substituted pyrazinone nucleosides--a new family of D4T analogues.

Abstract : The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by (1)H NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.
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Soumis le : jeudi 10 mai 2012 - 16:50:10
Dernière modification le : mardi 20 mars 2018 - 16:36:13




Nathalie Batoux, Robert Granet, Rachida Zerrouki, Pierre Krausz. 3-Substituted pyrazinone nucleosides--a new family of D4T analogues.. Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2009, 28 (9), pp.866-873. ⟨10.1080/15257770903169999⟩. ⟨hal-00696080⟩



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