3-Substituted pyrazinone nucleosides--a new family of D4T analogues. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nucleosides, Nucleotides and Nucleic Acids Année : 2009

3-Substituted pyrazinone nucleosides--a new family of D4T analogues.

, (1) , (1) , (1)
1
Nathalie Batoux
  • Fonction : Auteur

Résumé

The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by (1)H NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.
Fichier non déposé

Dates et versions

hal-00696080 , version 1 (10-05-2012)

Identifiants

Citer

Nathalie Batoux, Robert Granet, Rachida Zerrouki, Pierre Krausz. 3-Substituted pyrazinone nucleosides--a new family of D4T analogues.. Nucleosides, Nucleotides and Nucleic Acids, 2009, 28 (9), pp.866-873. ⟨10.1080/15257770903169999⟩. ⟨hal-00696080⟩
11 Consultations
2 Téléchargements

Altmetric

Partager

Gmail Facebook Twitter LinkedIn More