3-Substituted pyrazinone nucleosides--a new family of D4T analogues.

Nathalie Batoux; Robert Granet; Rachida Zerrouki; Pierre Krausz

doi:10.1080/15257770903169999

Article dans une revue

3-Substituted pyrazinone nucleosides--a new family of D4T analogues.

Nathalie Batoux Robert Granet ¹ Rachida Zerrouki ¹ Pierre Krausz ¹

1 LCSN - Laboratoire de Chimie des Substances Naturelles

Abstract : The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by (1)H NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.

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Article dans une revue

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Chimie / Chimie organique

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https://hal-unilim.archives-ouvertes.fr/hal-00696080
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Soumis le : jeudi 10 mai 2012 - 16:50:10
Dernière modification le : mardi 20 mars 2018 - 16:36:13

3-Substituted pyrazinone nucleosides--a new family of D4T analogues.

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