Chelation-controlled regioselective alkylation of pyrimidine 2'-deoxynucleosides. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Carbohydrate Research Année : 2010

Chelation-controlled regioselective alkylation of pyrimidine 2'-deoxynucleosides.

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Résumé

Protection-deprotection steps, which are usually needed for regioselective alkylation of pyrimidine deoxynucleosides, can be avoided by choosing the appropriate solvent. The combined effects of low dielectric constant and possible sodium chelation by pyrimidine nucleosides may account for the unexpected regioselectivity observed in THF.
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hal-00696222 , version 1 (11-05-2012)

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Romain Lucas, Karine Teste, Rachida Zerrouki, Yves Champavier, M. Guilloton. Chelation-controlled regioselective alkylation of pyrimidine 2'-deoxynucleosides.. Carbohydrate Research, 2010, 345 (2), pp.199-207. ⟨10.1016/j.carres.2009.10.021⟩. ⟨hal-00696222⟩
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