Pyrimidine-purine and pyrimidine heterodinucleosides synthesis containing a triazole linkage.

Romain Lucas (1) , Pierre-Henri Elchinger (1) , Pierre-Antoine Faugeras (1) , Rachida Zerrouki (1)

1 LCSN - Laboratoire de Chimie des Substances Naturelles

This article describes a synthetic route to generate two purine-pyrimidine and pyrimidine heterodinucleosides. Both microwave activated regioselective alkylation using hydride and copper-catalyzed-azide-alkyne-cycloaddition (CuAAC) were used in order to perform the synthesis.

Domaines: Chimie; Chimie organique

Romain Lucas, Pierre-Henri Elchinger, Pierre-Antoine Faugeras, Rachida Zerrouki. Pyrimidine-purine and pyrimidine heterodinucleosides synthesis containing a triazole linkage.. Nucleosides, Nucleotides and Nucleic Acids, 2010, 29 (3), pp.168-177. ⟨10.1080/15257771003708579⟩. ⟨hal-00696261⟩