Design and efficient synthesis of a new scaffold based on unsymmetrical protoporphyrin IX derivatives for use in SPPS.

M.-E. Bakleh (1) , Vincent Sol (1, 2) , Robert Granet (1) , Gérard Deleris (3) , K. Estieu-Gionnet (3) , Pierre Krausz (1)

1 LCSN - Laboratoire de Chimie des Substances Naturelles
2 Department of chemistry
3 CNAB - Chimie Nucléaire Analytique et Bio-environnementale

Fmoc-protected amine derivatives of Protoporphyrin IX were synthesized by two original methods using solid-phase chemistry. The new compounds represent unsymmetrical scaffolds suitable for the generation of a large range of peptidic porphyrin derivatives through SPPS strategy.

Domaines: Chimie organique

M.-E. Bakleh, Vincent Sol, Robert Granet, Gérard Deleris, K. Estieu-Gionnet, et al.. Design and efficient synthesis of a new scaffold based on unsymmetrical protoporphyrin IX derivatives for use in SPPS.. Chemical Communications, 2010, 46 (12), pp.2115-2117. ⟨10.1039/b922012g⟩. ⟨hal-00696957⟩