Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

An efficient route to VEGF-like peptide porphyrin conjugates via microwave-assisted 'click-chemistry'

Abstract : Synthetic cyclopeptides, and particularly those derived from VEGF sequence, present considerable interest for the development of nanodevices devoted to tumour imaging or targeting. In order to provide selective peptide-targeted tetrapyrrolic structures, we designed two meso-porphyrin derivatives anchored to a 17-residue-long cyclopeptide, potent antagonist of VEGF receptors, via a flexible tetraethylene glycol chain. Anchoring was achieved by two different strategies: a classical secondary amide bond formation and microwave-assisted Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition ('click-chemistry'). These compounds appear to be promising candidates for applications in PDT.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-00697324
Contributeur : Claire Douady <>
Soumis le : mardi 15 mai 2012 - 10:26:09
Dernière modification le : mardi 25 février 2020 - 16:16:12

Identifiants

Collections

Citation

M.-E. Bakleh, Vincent Sol, K. Estieu-Gionnet, Robert Granet, Gérard Deleris, et al.. An efficient route to VEGF-like peptide porphyrin conjugates via microwave-assisted 'click-chemistry'. Tetrahedron, Elsevier, 2009, 65 (36), pp.7385-7392. ⟨10.1016/j.tet.2009.07.028⟩. ⟨hal-00697324⟩

Partager

Métriques

Consultations de la notice

144