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Article dans une revue
An efficient route to VEGF-like peptide porphyrin conjugates via microwave-assisted 'click-chemistry'
Abstract : Synthetic cyclopeptides, and particularly those derived from VEGF sequence, present considerable interest for the development of nanodevices devoted to tumour imaging or targeting. In order to provide selective peptide-targeted tetrapyrrolic structures, we designed two meso-porphyrin derivatives anchored to a 17-residue-long cyclopeptide, potent antagonist of VEGF receptors, via a flexible tetraethylene glycol chain. Anchoring was achieved by two different strategies: a classical secondary amide bond formation and microwave-assisted Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition ('click-chemistry'). These compounds appear to be promising candidates for applications in PDT.
https://hal-unilim.archives-ouvertes.fr/hal-00697324
Contributeur : Claire Douady Connectez-vous pour contacter le contributeur
Soumis le : mardi 15 mai 2012 - 10:26:09
Dernière modification le : mercredi 20 octobre 2021 - 01:31:03
Contributeur : Claire Douady Connectez-vous pour contacter le contributeur
Soumis le : mardi 15 mai 2012 - 10:26:09
Dernière modification le : mercredi 20 octobre 2021 - 01:31:03
