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Dose-response effect of serum butyrylcholinesterase activity after clinical doses of pancuronium.

Abstract : INTRODUCTION: Low-dose pancuronium is known to affect serum cholinesterase activity (BChE); however, the dose-response effect of clinical doses of pancuronium on BChE has not been investigated. METHODS: Thirteen ASA I-II patients scheduled for elective surgery requiring muscle relaxation were enrolled in this study. All patients had normal BChE before surgery. Incremental doses of pancuronium (10, 20, 50, and 100 microg/kg) were injected in accordance with surgical needs every 45 min. BChE was measured 3 min after injection by an automatic colorimetric method. RESULTS: BChE decreased significantly in all except one patient in comparison to the baseline (P < 0.05). However all values remained within normal clinical range. A dose of 100 microg/kg yielded significant decrease in comparison to 10 microg/kg but not to other dosages. Linear regression was not significant for the dose-response relationship (P = 0.05). CONCLUSION: After clinical incremental doses of pancuronium, BChE remained within clinical range.
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Contributeur : Françoise Merigaud <>
Soumis le : mercredi 3 octobre 2012 - 11:15:32
Dernière modification le : lundi 22 janvier 2018 - 11:12:38

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C. Motamed, P. Fanen, P. Feiss, K. Kirov, P. Duvaldestin. Dose-response effect of serum butyrylcholinesterase activity after clinical doses of pancuronium.. European Journal of Clinical Pharmacology, Springer Verlag, 2008, 64 (11), pp.1043-5. ⟨10.1007/s00228-008-0548-9⟩. ⟨hal-00738010⟩

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