Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.

Nicolas Drogat; Robert Granet; Caroline Le Morvan; Gaëlle Bégaud-Grimaud; Pierre Krausz; Vincent Sol

doi:10.1016/j.bmcl.2012.04.044

Article dans une revue

Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.

Nicolas Drogat ¹ Robert Granet ¹ Caroline Le Morvan ¹ Gaëlle Bégaud-Grimaud ¹ Pierre Krausz ¹ Vincent Sol ¹

1 LCSN - Laboratoire de Chimie des Substances Naturelles

Abstract : This Letter reports the synthesis and characterization of a new series of water-stable and soluble photosensitizers (PS-CNCs) composed of cellulose nanocrystals (CNCs) bearing polyaminated chlorin p6. With a view to improve cancer cell targeting, these photosensitizers were assayed for their antitumor activity against HaCat cell line. IC(50) values fell within the nanomolar-range, making these photosensitizers promising for further in vitro and in vivo investigations.

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Article dans une revue

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Chimie / Chimie organique

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https://hal-unilim.archives-ouvertes.fr/hal-00800917
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Soumis le : jeudi 14 mars 2013 - 16:27:23
Dernière modification le : mercredi 20 octobre 2021 - 01:31:01

Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.

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