Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.

Nicolas Drogat (1) , Robert Granet (1) , Caroline Le Morvan (1) , Gaëlle Bégaud-Grimaud (1) , Pierre Krausz (1) , Vincent Sol (1)

1 LCSN - Laboratoire de Chimie des Substances Naturelles

This Letter reports the synthesis and characterization of a new series of water-stable and soluble photosensitizers (PS-CNCs) composed of cellulose nanocrystals (CNCs) bearing polyaminated chlorin p6. With a view to improve cancer cell targeting, these photosensitizers were assayed for their antitumor activity against HaCat cell line. IC(50) values fell within the nanomolar-range, making these photosensitizers promising for further in vitro and in vivo investigations.

Domaines: Chimie organique

Nicolas Drogat, Robert Granet, Caroline Le Morvan, Gaëlle Bégaud-Grimaud, Pierre Krausz, et al.. Chlorin-PEI-labeled cellulose nanocrystals: synthesis, characterization and potential application in PDT.. Bioorganic and Medicinal Chemistry Letters, 2012, 22 (11), pp.3648-52. ⟨10.1016/j.bmcl.2012.04.044⟩. ⟨hal-00800917⟩