Global cancer statistics, CA Cancer J Clin, vol.55, pp.74-108, 2002. ,
Apoptosis in the colonic crypt, colorectal adenomata, and manipulation by chemoprevention, Cancer epidemiol Biomarkers prev, vol.18, pp.1680-1687, 2009. ,
, AJCC (American Joint Committee on Cancer) Cancer staging Manual, p.113, 2002.
Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: a review, Biochim Biophys Acta, vol.1795, pp.117-129, 2009. ,
, JC: Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms, Nat Clin pract Oncol, vol.3, pp.388-398, 2006.
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br J Cancer, vol.26, pp.239-257, 1972. ,
, Hengartner MO: the biochemistry of apoptosis, Nature Lett, vol.407, pp.770-776, 2000.
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors, Cell Death Differ, vol.94, pp.481-490, 1998. ,
Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria, Biochimie, vol.84, pp.215-222, 2002. ,
Immunohistochemical and mutational analysis of apoptosis-inducing factor (AIF) in colorectal carcinomas, ApMIs, vol.114, pp.867-873, 2006. ,
Different cell thresholds for commitment to death: a link between carcinogenesis and drug resistance, Drug resist Updat, vol.1, pp.84-85, 1998. ,
Apoptosis and chemo-resistance in colorectal cancer, J surg Oncol, vol.96, pp.77-88, 2007. ,
Lessons from trAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy, Drug resist Updat, vol.7, pp.345-358, 2004. ,
D: the inhibitor of apoptosis protein family (IAps): an emerging therapeutic target in cancer. semin, Cancer Biol, vol.14, pp.231-243, 2004. ,
Changes in apoptosis during the development of colorectal cancer: a systematic review of the literature, Crit rev Oncol Hematol, vol.45, pp.37-53, 2003. ,
SA: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation, J Cell Biol, vol.119, pp.493-501, 1992. ,
Colorectal cancer surveillance: 2005 update of an American society of Clinical Oncology practice guideline, J Clin Oncol, vol.23, pp.8512-8519, 2005. ,
expression of trAIL (tNF-related apoptosis-inducing ligand) and its receptors in normal colonic mucosa, adenomas, and carcinomas, J pathol, vol.200, pp.327-335, 2003. ,
Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3, J Histochem Cytochem, vol.50, pp.449-454, 2002. ,
beta(2)-microglobulin induces apoptosis in HL-60 human leukemia cell line and its multidrug resistant variants overexpressing Mrp1 but lacking Bax or overexpressing p-glycoprotein, Oncogene, vol.20, pp.7006-7020, 2001. ,
Inhibition of glycogen synthase kinase-3beta down-regulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A, Brain res Dev Brain res, vol.3, pp.66-75, 2009. ,
pAst: paleontological statistics software package for education and Data Analysis, palaeontologia electronica, vol.4, p.9, 2001. ,
role of p53 and p21/ WAF1 detection in patient selection for preoperative radiotherapy in rectal cancer patients, Dis Colon rectum, vol.41, pp.68-74, 1998. ,
, Iacopetta B: tp53 mutation in colorectal cancer, Hum Mutat, vol.21, pp.271-276, 2003.
Apoptosis and colorectal cancer: implications for therapy, trends Mol Med, vol.15, pp.225-233, 2009. ,
TRAIL: a molecule with multiple receptors and control mechanisms, Curr Opin Immunol, vol.10, pp.559-563, 1998. ,
the potential role of Bcl-2 expression, apoptosis and cell proliferation (Ki-67 expression) in cases of gastric carcinoma and correlation with classic prognostic factors and patient outcome, Anticancer res, vol.29, pp.703-709, 2009. ,
Batistatou A and Vagianos C: potential role of bcl-2 and ki-67 expression and apoptosis in colorectal carcinoma: a clinicopathologic study, Dig Dis sci, vol.48, 1990. ,
the correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal carcinomas, J Morphol embryol, vol.48, pp.95-99, 2007. ,
Comparative analysis of prognostic significance of molecular markers of apoptosis with clinical stage and tumor differentiation in patients with colorectal cancer: a single institute experience, Hepatogastroenterology, vol.56, pp.94-98, 2009. ,
expression of trAIL and trAIL receptors in normal and malignant tissues, Cell res, vol.15, pp.430-438, 2005. ,
trAIL receptor up-regulation and the implication of KrAs/BrAF mutations in human colon cancer tumors, Int J Cancer, vol.125, pp.2127-2135, 2009. ,
prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand and its receptors in adjuvantly treated stage III colon cancer patients, J Clin Oncol, vol.24, pp.4998-5004, 2006. ,
Inhibition of apoptosis during development of colorectal cancer, Cancer res, vol.55, pp.1811-1816, 1995. ,
BCL-2, and Ki-67 expression according to tumor response after concurrent chemoradiotherapy for advanced rectal cancer, Ann surg Oncol, vol.8, pp.418-424, 2001. ,
potential role of bcl-2 expression and apoptotic body index in colorectal cancer, Hepatogastroenterology, vol.55, pp.76-81, 2008. ,
Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors, Arq Gastroenterol, vol.47, pp.141-147, 2010. ,