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Article dans une revue
TLR4 signal transduction pathways neutralize the effect of Fas signals on glioblastoma cell proliferation and migration.
Abstract : The Fas pathway is described as an activator of the glioblastoma proliferation by increasing the pathogenicity of this tumour. The lipopolysaccharide (LPS) pathway depending on Toll-like receptor 4 (TLR4) could limit the glioblastoma spreading. Here, Fas and TLR4 pathways were activated in glioblastoma cell lines by an agonist antibody and/or LPS treatment. Activation of the Fas pathway or of the TLR4 pathway induced cell proliferation. However, simultaneous treatment with agonist antibody and LPS decreased proliferation. This anti-proliferative effect was caspase dependent, and a decreased cell migration and matrix metalloproteinase (MMP)-9 expression were also observed. Both TLR4 and MMP-9 were highly expressed in human glioblastoma tissues. These data suggest that TLR4 signal transduction pathways neutralize proliferation and migration induced by Fas pathway activation in glioblastoma cell lines.
https://hal-unilim.archives-ouvertes.fr/hal-00873131
Contributeur : Philippe Sindou <>
Soumis le : mardi 15 octobre 2013 - 10:35:13
Dernière modification le : mardi 9 juin 2020 - 12:31:36
Contributeur : Philippe Sindou <>
Soumis le : mardi 15 octobre 2013 - 10:35:13
Dernière modification le : mardi 9 juin 2020 - 12:31:36
