RP-HPLC lipophilicity studies for some (hetero)arylamides derived from 2-amino 4,6-dimethyl pyridine: Introduction of an hydrogen-bond descriptor - Archive ouverte HAL Accéder directement au contenu
Autre Publication Scientifique Année : 2011

RP-HPLC lipophilicity studies for some (hetero)arylamides derived from 2-amino 4,6-dimethyl pyridine: Introduction of an hydrogen-bond descriptor

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Résumé

RP-HPLC measurements (in water+60% v/v acetonitrile, on a porous polystyrene column) lead to a linear calibration between the retention factor logk and the lipophilicity logP for a series of 9 OECD standards. Introduction of a variable indicator D for hydrogen-bond donors enhances the goodness of fit. From experimental retention factors, estimated values of logP are given for 23 substituted (hetero)arylcarboxamides derived from 2-amino 4,6-dimethyl pyridine, whose anti-inflammatory behavior and anti-cholinesterase activity were previously characterized. From the logP versus logk relationship, a family-dependent indicator variable D is attributed to each compound.
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Dates et versions

hal-00873163 , version 1 (15-10-2013)

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Dominique Cledat. RP-HPLC lipophilicity studies for some (hetero)arylamides derived from 2-amino 4,6-dimethyl pyridine: Introduction of an hydrogen-bond descriptor. 2011, pp.1356-1366. ⟨10.1080/10826076.2011.570842⟩. ⟨hal-00873163⟩

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