M. Matucci-cerinic, V. Steen, P. Nash, and E. Hachulla, The complexity of managing systemic sclerosis: screening and diagnosis, Rheumatology, vol.67, issue.suppl_3, pp.8-13, 2009.
DOI : 10.1136/ard.2007.079756
URL : https://academic.oup.com/rheumatology/article-pdf/48/suppl_3/iii8/18096131/ken482.pdf

L. Aloe, L. Bracci-laudiero, S. Bonini, and L. Manni, The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases, Allergy, vol.4, issue.Suppl 18, pp.883-894, 1997.
DOI : 10.14748/bmr.v4.186
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.1997.tb01247.x/pdf

L. Bracci-laudiero, L. Aloe, R. Levi-montalcini, M. Galeazzi, and D. Schilter, Increased levels of NGF in sera of systemic lupus erythematosus patients, NeuroReport, vol.4, issue.5, pp.563-565, 1993.
DOI : 10.1097/00001756-199305000-00025

A. Fauchais, A. Boumediene, F. Lalloue, G. Gondran, and V. Loustaud-ratti, Brain???derived neurotrophic factor and nerve growth factor correlate with T???cell activation in primary Sj??gren's syndrome, Scandinavian Journal of Rheumatology, vol.125, issue.1, pp.50-57, 2009.
DOI : 10.1046/j.1365-2249.2001.01623.x

M. Julio-pieper, P. Lozada, V. Tapia, M. Vega, and C. Miranda, Nerve Growth Factor Induces Vascular Endothelial Growth Factor Expression in Granulosa Cells via a trkA Receptor/Mitogen-Activated Protein Kinase-Extracellularly Regulated Kinase 2-Dependent Pathway, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.8, pp.3065-3071, 2009.
DOI : 10.1210/jc.2009-0542
URL : https://academic.oup.com/edrv/article-pdf/30/5/541/8863392/edrv0541a.pdf

P. Kermani and B. Hempstead, Brain-Derived Neurotrophic Factor: A Newly Described Mediator of Angiogenesis, Trends in Cardiovascular Medicine, vol.17, issue.4, pp.140-143, 2007.
DOI : 10.1016/j.tcm.2007.03.002
URL : http://europepmc.org/articles/pmc2268985?pdf=render

L. Manni, V. Nikolova, D. Vyagova, G. Chaldakov, and L. Aloe, Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes, International Journal of Cardiology, vol.102, issue.1, pp.169-171, 2005.
DOI : 10.1016/j.ijcard.2004.10.041

M. Xu, C. Remillard, B. Sachs, A. Makino, and O. Platoshyn, p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction, American Journal of Physiology-Heart and Circulatory Physiology, vol.295, issue.4, pp.1529-1538, 2008.
DOI : 10.1152/ajpheart.00968.2007
URL : http://ajpheart.physiology.org/content/ajpheart/295/4/H1529.full.pdf

A. Micera, E. Vigneti, D. Pickholtz, R. Reich, and O. Pappo, Nerve growth factor displays stimulatory effects on human skin and lung fibroblasts, demonstrating a direct role for this factor in tissue repair, Proceedings of the National Academy of Sciences, vol.8, issue.3, pp.6162-6167, 2001.
DOI : 10.1016/S1359-6101(97)00010-5
URL : http://www.pnas.org/content/98/11/6162.full.pdf

M. Coassin, A. Lambiase, A. Micera, P. Tirassa, and L. Aloe, Nerve growth factor modulates in vitro the expression and release of TGF-??1 by amniotic membrane, Graefe's Archive for Clinical and Experimental Ophthalmology, vol.42, issue.4, pp.485-491, 2006.
DOI : 10.1016/S1542-0124(12)70059-9

A. Micera, I. Puxeddu, A. Lambiase, A. Antonelli, and S. Bonini, The pro-fibrogenic effect of nerve growth factor on conjunctival fibroblasts is mediated by transforming growth factor-beta, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.90, issue.5, pp.650-656, 2005.
DOI : 10.1111/j.1432-1033.2004.03994.x

C. Denton and D. Abraham, Transforming growth factor-?? and connective tissue growth factor: key cytokines in scleroderma pathogenesis, Current Opinion in Rheumatology, vol.13, issue.6, pp.505-511, 2001.
DOI : 10.1097/00002281-200111000-00010

M. Tuveri, G. Passiu, A. Mathieu, and L. Aloe, Nerve growth factor and mast cell distribution in the skin of patients with systemic sclerosis, Clin Exp Rheumatol, vol.11, pp.319-322, 1993.

M. Matucci-cerinic, R. Giacomelli, A. Pignone, M. Cagnoni, and S. Generini, Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma), Annals of the Rheumatic Diseases, vol.60, issue.5, pp.487-494, 2001.
DOI : 10.1136/ard.60.5.487
URL : http://ard.bmj.com/content/annrheumdis/60/5/487.full.pdf

L. Lonzetti, F. Joyal, J. Raynauld, A. Roussin, and J. Goulet, Updating the American College of Rheumatology preliminary classification criteria for systemic sclerosis: Addition of severe nailfold capillaroscopy abnormalities markedly increases the sensitivity for limited scleroderma, Arthritis & Rheumatism, vol.24, issue.3, pp.735-736, 2001.
DOI : 10.1002/1529-0131(200103)44:3<735::AID-ANR125>3.0.CO;2-F

T. Medsger and V. Steen, Classification, prognosis, Systemic sclerosis, pp.51-79, 1996.

Z. Yang, D. Ho, C. Lau, K. Tam, and C. Lam, Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports, vol.16, pp.1237-1243, 2006.
DOI : 10.3892/or.16.6.1237

E. Leroy, C. Black, R. Fleischmajer, S. Jablonska, and T. Krieg, Scleroderma (systemic sclerosis): classification, subsets and pathogenesis, J Rheumatol, vol.15, pp.202-205, 1988.

P. Clements, P. Lachenbruch, J. Siebold, B. White, and S. Weiner, Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis, J Rheumatol, vol.22, pp.1281-1285, 1995.

T. Medsger, J. Bombardieri, S. Czirjak, L. Scorza, R. et al., Assessment of disease severity and prognosis, Clin Exp Rheumatol, vol.21, pp.42-46, 2003.

H. Kawaguchi-manabe, M. Ieda, K. Kimura, T. Manabe, and S. Miyatake, A novel cardiac hypertrophic factor, neurotrophin-3, is paradoxically downregulated in cardiac hypertrophy, Life Sciences, vol.81, issue.5, pp.385-392, 2007.
DOI : 10.1016/j.lfs.2007.05.024

M. Piga, G. Passiu, P. Carta, L. Satta, and V. Cherchi, Increased pulmonary epithelial permeability in systemic sclerosis is associated with enhanced cutaneous nerve growth factor expression, European Journal of Internal Medicine, vol.11, issue.3, pp.156-160, 2000.
DOI : 10.1016/S0953-6205(00)00084-4

E. Dicou, C. Masson, W. Jabbour, and V. Nerriere, Increased frequency of NGF in sera of rheumatoid arthritis and systemic lupus erythematosus patients, NeuroReport, vol.5, issue.3, pp.321-324, 1993.
DOI : 10.1097/00001756-199312000-00036

K. Aalto, L. Korhonen, P. Lahdenne, P. Pelkonen, and D. Lindholm, NERVE GROWTH FACTOR IN SERUM OF CHILDREN WITH SYSTEMIC LUPUS ERYTHEMATOSUS IS CORRELATED WITH DISEASE ACTIVITY, Cytokine, vol.20, issue.3, pp.136-139, 2002.
DOI : 10.1006/cyto.2002.1991

M. Seidel, M. Herguijuela, R. Forkert, and U. Otten, Nerve Growth Factor in Rheumatic Diseases, Seminars in Arthritis and Rheumatism, vol.40, issue.2, 2009.
DOI : 10.1016/j.semarthrit.2009.03.002

U. Otten, P. Ehrhard, and R. Peck, Nerve growth factor induces growth and differentiation of human B lymphocytes., Proceedings of the National Academy of Sciences, vol.86, issue.24, pp.10059-10063, 1989.
DOI : 10.1073/pnas.86.24.10059
URL : http://www.pnas.org/content/86/24/10059.full.pdf

M. Torcia, L. Bracci-laudiero, M. Lucibello, L. Nencioni, and D. Labardi, Nerve Growth Factor Is an Autocrine Survival Factor for Memory B Lymphocytes, Cell, vol.85, issue.3, pp.345-356, 1996.
DOI : 10.1016/S0092-8674(00)81113-7
URL : https://doi.org/10.1016/s0092-8674(00)81113-7

O. Noga, G. Hanf, C. Schaper, O. Connor, A. Kunkel et al., The influence of inhalative corticosteroids on circulating Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin-3 in allergic asthmatics, Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, vol.2, issue.2, pp.1906-1912, 2001.
DOI : 10.1016/0896-6273(91)90265-2

O. Grimsholm, S. Rantapaa-dahlqvist, T. Dalen, and S. Forsgren, BDNF in RA: Downregulated in plasma following anti-TNF treatment but no correlation with inflammatory parameters, Clinical Rheumatology, vol.14, issue.10, pp.1289-1297, 2008.
DOI : 10.1007/BF02389889

F. Del-porto, L. Aloe, B. Lagana, V. Triaca, and I. Nofroni, Nerve Growth Factor and Brain-Derived Neurotrophic Factor Levels in Patients with Rheumatoid Arthritis Treated with TNF-?? Blockers, Annals of the New York Academy of Sciences, vol.5, issue.1, pp.438-443, 2006.
DOI : 10.1016/S0091-3057(02)00757-8

T. Nakahashi, H. Fujimura, C. Altar, J. Li, and J. Kambayashi, Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor, FEBS Letters, vol.245, issue.2, pp.113-117, 2000.
DOI : 10.1006/bbrc.1998.8418
URL : http://onlinelibrary.wiley.com/doi/10.1016/S0014-5793(00)01302-8/pdf

M. Kerschensteiner, E. Gallmeier, L. Behrens, V. Leal, and T. Misgeld, Activated Human T Cells, B Cells, and Monocytes Produce Brain-derived Neurotrophic Factor In Vitro and in Inflammatory Brain Lesions: A Neuroprotective Role of Inflammation?, The Journal of Experimental Medicine, vol.58, issue.5, pp.865-870, 1999.
DOI : 10.1093/brain/120.5.865

M. Besser and R. Wank, Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1/Th2-polarized expression of their receptors, J Immunol, vol.162, pp.6303-6306, 1999.

C. Barthel, N. Yeremenko, R. Jacobs, R. Schmidt, and M. Bernateck, Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis, Arthritis Research & Therapy, vol.11, issue.3, p.82, 2009.
DOI : 10.1186/ar2716
URL : https://arthritis-research.biomedcentral.com/track/pdf/10.1186/ar2716?site=arthritis-research.biomedcentral.com

M. Rihl, E. Kruithof, C. Barthel, D. Keyser, F. Veys et al., Involvement of neurotrophins and their receptors in spondyloarthritis synovitis: relation to inflammation and response to treatment, Annals of the Rheumatic Diseases, vol.64, issue.11, pp.1542-1551, 2005.
DOI : 10.1136/ard.2004.032599
URL : http://ard.bmj.com/content/annrheumdis/64/11/1542.full.pdf

M. Donovan, R. Miranda, R. Kraemer, T. Mccaffrey, and L. Tessarollo, Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury, Am J Pathol, vol.147, pp.309-324, 1995.

M. Donovan, M. Lin, P. Wiegn, T. Ringstedt, and R. Kraemer, Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization, Development, vol.127, pp.4531-4540, 2000.

A. Ricci, S. Greco, F. Amenta, E. Bronzetti, and L. Felici, Neurotrophins and Neurotrophin Receptors in Human Pulmonary Arteries, Journal of Vascular Research, vol.37, issue.5, pp.355-363, 2000.
DOI : 10.1159/000025751

P. Kermani, D. Rafii, D. Jin, P. Whitlock, and W. Schaffer, Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors, Journal of Clinical Investigation, vol.115, issue.3, pp.653-663, 2005.
DOI : 10.1172/JCI22655DS1

G. Chaldakov, M. Fiore, I. Stankulov, M. Hristova, and A. Antonelli, NGF, BDNF, Leptin, and Mast Cells in Human Coronary Atherosclerosis and Metabolic Syndrome, Archives of Physiology and Biochemistry, vol.96, issue.1, pp.357-360, 2001.
DOI : 10.1016/S0002-9440(10)64640-8

A. Wu, Z. Ying, and F. Gomez-pinilla, The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition, European Journal of Neuroscience, vol.22, issue.7, pp.1699-1707, 2004.
DOI : 10.1523/JNEUROSCI.22-05-01532.2002

F. Kapczinski, B. Frey, A. Andreazza, M. Kauer-sant-'anna, and A. Cunha, Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes, Revista Brasileira de Psiquiatria, vol.31, issue.1, pp.243-245, 2008.
DOI : 10.1016/j.pnpbp.2006.06.011
URL : http://www.scielo.br/pdf/rbp/v30n3/a11v30n3.pdf

F. Ogawa, K. Shimizu, E. Muroi, T. Hara, and M. Hasegawa, Serum levels of 8-isoprostane, a marker of oxidative stress, are elevated in patients with systemic sclerosis, Rheumatology, vol.45, issue.7, pp.815-818, 2006.
DOI : 10.1038/nm0397-276

Y. Iwata, F. Ogawa, K. Komura, E. Muroi, and T. Hara, Autoantibody against peroxiredoxin I, an antioxidant enzyme, in patients with systemic sclerosis: possible association with oxidative stress, Rheumatology, vol.46, issue.5, pp.790-795, 2007.
DOI : 10.1093/rheumatology/kem010
URL : https://academic.oup.com/rheumatology/article-pdf/46/5/790/6701361/kem010.pdf

A. Santhanam, L. Smith, and Z. Katusic, Brain-Derived Neurotrophic Factor Stimulates Production of Prostacyclin in Cerebral Arteries * Supplemental Data, Stroke, vol.41, issue.2, pp.350-356
DOI : 10.1161/STROKEAHA.109.564492
URL : http://stroke.ahajournals.org/content/strokeaha/41/2/350.full.pdf

B. Chul, I. Choi, Y. Kim, B. Ham, and B. Yang, Relation between plasma brain-derived neurotrophic factor and nerve growth factor in the male patients with alcohol dependence, Alcohol, vol.43, issue.4, pp.265-269, 2009.
DOI : 10.1016/j.alcohol.2009.04.003

L. Kasselman, A. Sideris, C. Bruno, W. Perez, and N. Cai, BDNF: A missing link between sympathetic dysfunction and inflammatory disease?, Journal of Neuroimmunology, vol.175, issue.1-2, pp.118-127, 2006.
DOI : 10.1016/j.jneuroim.2006.03.008

J. Goss, K. Taffe, P. Kochanek, and S. Dekosky, The Antioxidant Enzymes Glutathione Peroxidase and Catalase Increase Following Traumatic Brain Injury in the Rat, Experimental Neurology, vol.146, issue.1, pp.291-294, 1997.
DOI : 10.1006/exnr.1997.6515

T. Abe, D. Morgan, and D. Gutterman, Protective Role of Nerve Growth Factor Against Postischemic Dysfunction of Sympathetic Coronary Innervation, Circulation, vol.95, issue.1, pp.213-220, 1997.
DOI : 10.1161/01.CIR.95.1.213

J. Hiltunen, A. Laurikainen, A. Vakeva, S. Meri, and M. Saarma, Nerve growth factor and brain-derived neurotrophic factor mRNAs are regulated in distinct cell populations of rat heart after ischaemia and reperfusion, The Journal of Pathology, vol.512, issue.2, pp.247-253, 2001.
DOI : 10.1111/j.1469-7793.1998.779bd.x

N. Assous, Y. Allanore, F. Batteux, C. Meune, and P. Toulon, Prevalence of antiphospholipid antibodies in systemic sclerosis and association with primitive pulmonary arterial hypertension and endothelial injury, Clin Exp Rheumatol, vol.23, pp.199-204, 2005.

J. Delgado-alves, L. Mason, P. Ames, P. Chen, and J. Rauch, Antiphospholipid antibodies are associated with enhanced oxidative stress, decreased plasma nitric oxide and paraoxonase activity in an experimental mouse model, Rheumatology, vol.44, issue.10, pp.1238-1244, 2005.
DOI : 10.1016/S1089-8603(02)00005-8

S. Gupta, A. Saxena, U. Singh, and D. Arya, Bosentan, the mixed ETA???ETB endothelin receptor antagonist, attenuated oxidative stress after experimental myocardial ischemia and reperfusion, Molecular and Cellular Biochemistry, vol.173, issue.suppl IV, pp.67-74, 2005.
DOI : 10.1161/01.CIR.73.5.1065