In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment.

Eliane Bourreau (1) , Catherine Ronet (2) , Edith Darsissac (1) , Marie-Claire Lise (1) , Dominique Sainte Marie (3) , Emmanuel Clity (3) , Fabienne Tacchini-Cottier (2) , Pierre Couppié (3) , Pascal Launois (1, 2)

1 Institut Pasteur de la Guyane
2 WHO-IRTC - Department of Biochemistry
3 Institut Guyanais de Dermatologie Tropicale

The presence of intralesional natural regulatory T cells, characterized by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate. Foxp3 mRNA levels were associated with unresponsiveness to treatment among patients with a lesion duration of 1 month, but this association was not observed among patients with a lesion duration of <1 month. In conclusion, high intralesional expression of Foxp3 might be an indicator of poor response to treatment, depending on the duration of lesions.

Domaines: Biologie cellulaire

Eliane Bourreau, Catherine Ronet, Edith Darsissac, Marie-Claire Lise, Dominique Sainte Marie, et al.. In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment.. Journal of Infectious Diseases, 2009, 199 (4), pp.576-9. ⟨10.1086/596508⟩. ⟨hal-00911620⟩