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In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment.
Abstract : The presence of intralesional natural regulatory T cells, characterized by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate. Foxp3 mRNA levels were associated with unresponsiveness to treatment among patients with a lesion duration of 1 month, but this association was not observed among patients with a lesion duration of <1 month. In conclusion, high intralesional expression of Foxp3 might be an indicator of poor response to treatment, depending on the duration of lesions.
https://hal-unilim.archives-ouvertes.fr/hal-00911620
Contributeur : Philippe Sindou Connectez-vous pour contacter le contributeur
Soumis le : vendredi 29 novembre 2013 - 14:49:06
Dernière modification le : jeudi 30 septembre 2021 - 16:00:03
Contributeur : Philippe Sindou Connectez-vous pour contacter le contributeur
Soumis le : vendredi 29 novembre 2013 - 14:49:06
Dernière modification le : jeudi 30 septembre 2021 - 16:00:03
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