Arrêt de service lundi 11 juillet de 12h30 à 13h : tous les sites du CCSD (HAL, Epiciences, SciencesConf, AureHAL) seront inaccessibles (branchement réseau à modifier)
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages.

Abstract : Marked phenotypic variation characterizes isolates of Toxoplasma gondii, a ubiquitous zoonotic parasite that serves as an important experimental model for studying apicomplexan parasites. Progress in identifying the heritable basis for clinically and epidemiologically significant differences requires a robust system for describing and interpreting evolutionary subdivisions in this prevalent pathogen. To develop such a system, we have examined more than 950 isolates collected from around the world and genotyped them using three independent sets of polymorphic DNA markers, sampling 30 loci distributed across all nuclear chromosomes as well as the plastid genome. Our studies reveal a biphasic pattern consisting of regions in the Northern Hemisphere where a few, highly clonal and abundant lineages predominate; elsewhere, and especially in portions of South America are characterized by a diverse assemblage of less common genotypes that show greater evidence of recombination. Clustering methods were used to organize the marked genetic diversity of 138 unique genotypes into 15 haplogroups that collectively define six major clades. Analysis of gene flow indicates that a small number of ancestral lineages gave rise to the existing diversity through a process of limited admixture. Identification of reference strains for these major groups should facilitate future studies on comparative genomics and identification of genes that control important biological phenotypes including pathogenesis and transmission.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Benoît Marin Connectez-vous pour contacter le contributeur
Soumis le : mercredi 18 décembre 2013 - 12:24:45
Dernière modification le : mardi 31 mai 2022 - 10:20:13

Lien texte intégral




Chunlei Su, Asis Khan, Peng Zhou, Debashree Majumdar, Daniel Ajzenberg, et al.. Globally diverse Toxoplasma gondii isolates comprise six major clades originating from a small number of distinct ancestral lineages.. Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (15), pp.5844-9. ⟨10.1073/pnas.1203190109⟩. ⟨hal-00920379⟩



Consultations de la notice