Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.

Theo Vos Abraham D Flaxman Mohsen Naghavi Rafael Lozano Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans 1, 2 Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M Baddour Adil N Bahalim Suzanne Barker-Collo Lope H Barrero David H Bartels Maria-Gloria Basáñez Amanda Baxter Michelle L Bell Emelia J Benjamin Derrick Bennett Eduardo Bernabé Kavi Bhalla Bishal Bhandari Boris Bikbov Aref Bin Abdulhak Gretchen Birbeck James A Black Hannah Blencowe Jed D Blore Fiona Blyth Ian Bolliger Audrey Bonaventure Soufiane Boufous Rupert Bourne Michel Boussinesq Tasanee Braithwaite Carol Brayne 3 Lisa Bridgett Simon Brooker Peter Brooks 4 Traolach S Brugha Claire Bryan-Hancock Chiara Bucello Rachelle Buchbinder Geoffrey Buckle Christine M Budke 5 Michael Burch Peter Burney 6 Roy Burstein Bianca Calabria Benjamin Campbell Charles E Canter Hélène Carabin Jonathan Carapetis Loreto Carmona Claudia Cella Fiona Charlson Honglei Chen Andrew Tai-Ann Cheng David Chou Sumeet S Chugh Luc E Coffeng Steven D Colan Samantha Colquhoun K Ellicott Colson John Condon Myles D Connor Leslie T Cooper Matthew Corriere Monica Cortinovis Karen Courville de Vaccaro William Couser Benjamin C Cowie Michael H Criqui Marita Cross Kaustubh C Dabhadkar Manu Dahiya Nabila Dahodwala James Damsere-Derry Goodarz Danaei Adrian Davis Diego de Leo Louisa Degenhardt Robert Dellavalle Allyne Delossantos Julie Denenberg Sarah Derrett Don C Des Jarlais Samath D Dharmaratne Mukesh Dherani Cesar Diaz-Torne Helen Dolk 7 E Ray Dorsey Tim Driscoll Herbert Duber Beth Ebel Karen Edmond Alexis Elbaz 8 Suad Eltahir Ali Holly Erskine Patricia J Erwin Patricia Espindola Stalin E Ewoigbokhan Farshad Farzadfar Valery Feigin David T Felson Alize Ferrari Cleusa P Ferri Eric M Fèvre Mariel M Finucane Seth Flaxman Louise Flood Kyle Foreman Mohammad H Forouzanfar Francis Gerry R Fowkes Richard Franklin Marlene Fransen Michael K Freeman Belinda J Gabbe Sherine E Gabriel Emmanuela Gakidou Hammad A Ganatra Bianca Garcia Flavio Gaspari Richard F Gillum Gerhard Gmel Richard Gosselin Rebecca Grainger Justina Groeger Francis Guillemin 9, 10 David Gunnell 11 Ramyani Gupta Juanita Haagsma Holly Hagan Yara A Halasa Wayne Hall Diana Haring Josep Maria Haro James E Harrison Rasmus Havmoeller Roderick J Hay Hideki Higashi Catherine Hill Bruno Hoen 12, 13 Howard Hoffman Peter J Hotez Damian Hoy John J Huang Sydney E Ibeanusi Kathryn H Jacobsen Spencer L James Deborah Jarvis 14 Rashmi Jasrasaria Sudha Jayaraman Nicole Johns Jost B Jonas Ganesan Karthikeyan Nicholas Kassebaum Norito Kawakami Andre Keren Jon-Paul Khoo Charles H King Lisa Marie Knowlton Olive Kobusingye Adofo Koranteng Rita Krishnamurthi Ratilal Lalloo Laura L Laslett Tim Lathlean Janet L Leasher Yong Yi Lee James Leigh Stephen S Lim Elizabeth Limb John Kent Lin Michael Lipnick Steven E Lipshultz Wei Liu Maria Loane 7 Summer Lockett Ohno Ronan Lyons Jixiang Ma Jacqueline Mabweijano Michael F Macintyre Reza Malekzadeh 15 Leslie Mallinger Sivabalan Manivannan Wagner Marcenes Lyn March David J Margolis Guy B Marks Robin Marks Akira Matsumori Richard Matzopoulos Bongani M Mayosi John H Mcanulty Mary M Mcdermott Neil Mcgill 16 John Mcgrath Maria Elena Medina-Mora Michele Meltzer George A Mensah Tony R Merriman Ana-Claire Meyer Valeria Miglioli Matthew Miller 17 Ted R Miller Philip B Mitchell Ana Olga Mocumbi Terrie E Moffitt Ali A Mokdad Lorenzo Monasta Marcella Montico Maziar Moradi-Lakeh Andrew Moran Lidia Morawska Rintaro Mori Michele E Murdoch Michael K Mwaniki Kovin Naidoo M Nathan Nair Luigi Naldi 18 K M Venkat Narayan Paul K Nelson Robert G Nelson Michael C Nevitt Charles R Newton Sandra Nolte Paul Norman Rosana Norman Martin O'Donnell Simon O'Hanlon Casey Olives Saad B Omer Katrina Ortblad Richard Osborne Doruk Ozgediz Andrew Page Bishnu Pahari Jeyaraj Durai Pandian Andrea Panozo Rivero Scott B Patten Neil Pearce 19 Rogelio Perez Padilla Fernando Perez-Ruiz Norberto Perico Konrad Pesudovs David Phillips 20 Michael R Phillips Kelsey Pierce Sébastien Pion Guilherme V Polanczyk Suzanne Polinder C Arden Pope Svetlana Popova Esteban Porrini Farshad Pourmalek Martin Prince 21 Rachel L Pullan Kapa D Ramaiah Dharani Ranganathan Homie Razavi Mathilda Regan Jürgen T Rehm David B Rein Guiseppe Remuzzi Kathryn Richardson Frederick P Rivara Thomas Roberts Carolyn Robinson Felipe Rodriguez de Leòn Luca Ronfani Robin Room Lisa C Rosenfeld Lesley Rushton Ralph L Sacco 22 Sukanta Saha Uchechukwu Sampson Lidia Sanchez-Riera Ella Sanman David C Schwebel James Graham Scott Maria Segui-Gomez Saeid Shahraz Donald S Shepard Hwashin Shin Rupak Shivakoti David Singh Gitanjali M Singh Jasvinder A Singh Jessica Singleton David A Sleet Karen Sliwa Emma Smith Jennifer L Smith Nicolas J C Stapelberg Andrew Steer Timothy Steiner Wilma A Stolk Lars Jacob Stovner Christopher Sudfeld Sana Syed Giorgio Tamburlini 23 Mohammad Tavakkoli Hugh R Taylor Jennifer A Taylor William J Taylor Bernadette Thomas 24 W Murray Thomson George D Thurston Imad M Tleyjeh Marcello Tonelli Jeffrey A Towbin Thomas Truelsen Miltiadis K Tsilimbaris Clotilde Ubeda Eduardo A Undurraga Marieke J van der Werf Jim van Os 25 Monica S Vavilala N. Venketasubramanian Mengru Wang Wenzhi Wang Kerrianne Watt David J Weatherall 26 Martin A Weinstock Robert Weintraub Marc G Weisskopf Myrna M Weissman Richard A White Harvey Whiteford Steven T Wiersma James D Wilkinson Hywel C Williams Sean R M Williams Emma Witt Frederick Wolfe Anthony D Woolf Sarah Wulf Pon-Hsiu Yeh Anita K M Zaidi Zhi-Jie Zheng David Zonies Alan D Lopez Christopher J L Murray * Mohammad A Almazroa Ziad A Memish
Abstract : BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs). METHODS: Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis. FINDINGS: Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350,000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0*37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa. INTERPRETATION: Rates of YLDs per 100,000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world. FUNDING: Bill & Melinda Gates Foundation.
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Soumis le : vendredi 20 décembre 2013 - 15:43:40
Dernière modification le : vendredi 8 novembre 2019 - 10:48:02

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Theo Vos, Abraham D Flaxman, Mohsen Naghavi, Rafael Lozano, Catherine Michaud, et al.. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.. Lancet, Elsevier, 2012, 380 (9859), pp.2163-96. ⟨10.1016/S0140-6736(12)61729-2⟩. ⟨hal-00921555⟩

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