Microwave biosensors for identifying cancer cell aggressiveness grade

Ling Yan Zhang (1) , Christophe Bounaix Morand Du Puch (2) , Aurélie Lacroix , Claire Dalmay (1) , Arnaud Pothier (1) , Christophe Lautrette (2) , Serge Battu (3) , Fabrice Lalloué (3) , Marie-Odile Jauberteau-Marchan (3, 4) , Pierre Blondy (1)

1 XLIM-MINACOM - MINACOM
2 ONCOMEDICS SAS
3 HCP - Homéostasie Cellulaire et Pathologies
4 Service d'Immunologie et immunogénétique [CHU Limoges]

This paper illustrates the potential of microwave frequencies for biological analysis. Once penetrating inside biological cells, microwaves can interact with their intracellular content and inform on their safe or malignant state. This work demonstrates that their cancer grade (i.e. aggressiveness level) can also be identified by this way. Hence, based on permittivity measurements on three colon cancer cell lines loading RF resonators, the presented results show significant differences of electromagnetic signature in the cancer grade of analyzed cells. This sensing method appears very promising to develop new powerful tools for early cancer diagnostic.

Mots clés: Biology; Biosensors; Cancer; Frequency measurement; Microwave theory and techniques; Permittivity; Resonant frequency

Domaines: Sciences de l'ingénieur [physics]; Micro et nanotechnologies/Microélectronique

Ling Yan Zhang, Christophe Bounaix Morand Du Puch, Aurélie Lacroix, Claire Dalmay, Arnaud Pothier, et al.. Microwave biosensors for identifying cancer cell aggressiveness grade. IEEE MTT-S International, Jun 2012, Montreal, QC, Canada. pp.1 - 3, ⟨10.1109/MWSYM.2012.6259539⟩. ⟨hal-00923028⟩