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Article Dans Une Revue Tetrahedron Letters Année : 2011

Design of a new oligotriazole peptide nucleic acid analogue (oT-PNA)

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Résumé

We describe in this Letter the synthesis of an original thymine azido-heterotrimer generated by Click Chemistry. This trimer has been obtained from an azido-thymidine and a new chloroethyl-propargylated PNA monomer analogue, after two azidation/click-reaction cycles. Conformational preferences of a rotameric intermediate have also been studied.
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hal-00926590 , version 1 (09-01-2014)

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Julien Vergnaud, Pierre-Antoine Faugeras, Vincent Chaleix, Yves Champavier, Rachida Zerrouki. Design of a new oligotriazole peptide nucleic acid analogue (oT-PNA). Tetrahedron Letters, 2011, 52 (46), pp.6185-6189. ⟨10.1016/j.tetlet.2011.09.050⟩. ⟨hal-00926590⟩
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