One-pot and catalyst-free amidation of ester: A matter of non-bonding interactions

Olivier Rezazgui; Benjamin Boëns; Karine Teste; Julien Vergnaud; Patrick Trouillas; Rachida Zerrouki

One-pot and catalyst-free amidation of ester: A matter of non-bonding interactions

Olivier Rezazgui ¹ Benjamin Boëns ¹ Karine Teste ¹ Julien Vergnaud ¹ Patrick Trouillas ¹ Rachida Zerrouki ^{1, *}

* Auteur correspondant

1 LCSN - Laboratoire de Chimie des Substances Naturelles

Abstract : This paper describes a one-pot procedure for acetamide synthesis directly from amines and pyrimidine ester, without any catalyst or coupling agents. The inexpensive and simple reaction conditions are the most important features of this amidation. This reaction was performed with various amines, showing that long range stabilizing interactions (H-bonding and π-stacking) are the driving force for chemoselectivity.

Type de document :

Article dans une revue

Domaine :

Chimie / Chimie organique

Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-00926592
Contributeur : Vincent Sol <>
Soumis le : jeudi 9 janvier 2014 - 19:05:20
Dernière modification le : mardi 20 mars 2018 - 16:36:43

One-pot and catalyst-free amidation of ester: A matter of non-bonding interactions

Identifiants

Collections

Citation

Exporter

Métriques

146

One-pot and catalyst-free amidation of ester: A matter of non-bonding interactions

Identifiants

Collections

Citation

Exporter

Partager

Métriques

146