Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis.

Agathe Paubel; Jeremy Violette; Maïté Amy; Julien Praline; Vincent Meininger; William Camu; Philippe Corcia; Christian R Andres; Patrick Vourc'H; French Amyotrophic Lateral Sclerosis Als Group

Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis.

Agathe Paubel ¹ Jeremy Violette Maïté Amy Julien Praline Vincent Meininger ² William Camu ³ Philippe Corcia ⁴ Christian R Andres ^{5, *} Patrick Vourc'H ⁵ French Amyotrophic Lateral Sclerosis Als Group ⁶

* Auteur correspondant

1 Service de génétique [Tours]

2 Fédération des Maladies du Système Nerveux

3 SLA CHRU Montpellier - Centre référent Sclérose Latérale Amyotrophique [CHRU Montpellier]

4 Centre SLA

5 Imagerie et cerveau

6 NETEC - Neuroépidémiologie Tropicale et Comparée

Abstract : BACKGROUND: Mutations in the angiogenin gene, ANG, have been associated recently with familial and sporadic forms of amyotrophic lateral sclerosis (ALS). However, the cellular and molecular mechanisms that link ANG, a multidomain protein, to ALS are still unknown. OBJECTIVE: To assess the frequency of ANG gene mutations in 855 French patients with sporadic ALS. DESIGN: We analyzed by direct sequencing the full coding region of the ANG gene in a cohort of French patients with sporadic ALS. The clinical characteristics of patients carrying ANG mutations are detailed. SETTING: French ALS Study Group. Patients A total of 855 patients with sporadic ALS. MAIN OUTCOME MEASURES: Results of genetic analyses. RESULTS: We observed a previously identified mutation (pI46V) in 2 patients with ALS without a known family link and found a novel mutation (pR121H) in 1 patient who developed ALS with rapid progression. We did not observe an association between patients with ALS and the rs11701 polymorphism, as previously reported in certain ALS populations of other ethnic origins. CONCLUSION: Overall, our findings support the implication of ANG gene mutations as a rare but widespread cause of ALS.

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-00926684
Contributeur : Elisabeth Grelier <>
Soumis le : vendredi 10 janvier 2014 - 09:33:38
Dernière modification le : jeudi 11 juillet 2019 - 16:04:02

Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis.

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Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis.

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