Evaluation of the usefulness of six commercial agglutination assays for serologic diagnosis of toxoplasmosis. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Diagnostic Microbiology and Infectious Disease Année : 2012

Evaluation of the usefulness of six commercial agglutination assays for serologic diagnosis of toxoplasmosis.

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Résumé

Six agglutination tests for detecting Toxoplasma gondii-specific antibodies (immunoglobulin G or M) in serum were performed and compared. In total, 599 sera were examined using direct and indirect agglutination assays. Sensitivity varied from 93.7% to 100% and specificity from 97.1% to 99.2%. In a selected population with interfering diseases, the percentage of false positives ranged from 4.3% to 10.9%. Although an overall agreement of 100% was found for chronic toxoplasmosis, sensitivity for the detection of confirmed acute toxoplasmosis ranged from 86.4% to 97.3%. Regarding the large variability in terms of the performance of the 6 assays, tests based on the hemagglutination principle were found to be better than the other agglutination tests for all the panels evaluated, meaning that they could be used as qualitative or semiquantitative low-cost screening assays.
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Dates et versions

hal-00927582 , version 1 (13-01-2014)

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Citer

Odile Villard, Bernard Cimon, Jacqueline Franck, Hélène Fricker-Hidalgo, Nadine Godineau, et al.. Evaluation of the usefulness of six commercial agglutination assays for serologic diagnosis of toxoplasmosis.. Diagnostic Microbiology and Infectious Disease, 2012, 73 (3), pp.231-5. ⟨10.1016/j.diagmicrobio.2012.03.014⟩. ⟨hal-00927582⟩
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