Evaluation of the usefulness of six commercial agglutination assays for serologic diagnosis of toxoplasmosis.

Abstract : Six agglutination tests for detecting Toxoplasma gondii-specific antibodies (immunoglobulin G or M) in serum were performed and compared. In total, 599 sera were examined using direct and indirect agglutination assays. Sensitivity varied from 93.7% to 100% and specificity from 97.1% to 99.2%. In a selected population with interfering diseases, the percentage of false positives ranged from 4.3% to 10.9%. Although an overall agreement of 100% was found for chronic toxoplasmosis, sensitivity for the detection of confirmed acute toxoplasmosis ranged from 86.4% to 97.3%. Regarding the large variability in terms of the performance of the 6 assays, tests based on the hemagglutination principle were found to be better than the other agglutination tests for all the panels evaluated, meaning that they could be used as qualitative or semiquantitative low-cost screening assays.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-00927582
Contributeur : Elisabeth Grelier <>
Soumis le : lundi 13 janvier 2014 - 12:22:56
Dernière modification le : jeudi 11 avril 2019 - 16:02:22

Identifiants

Collections

Citation

Odile Villard, Bernard Cimon, Jacqueline Franck, Hélène Fricker-Hidalgo, Nadine Godineau, et al.. Evaluation of the usefulness of six commercial agglutination assays for serologic diagnosis of toxoplasmosis.. Diagnostic Microbiology and Infectious Disease, Elsevier, 2012, 73 (3), pp.231-5. ⟨10.1016/j.diagmicrobio.2012.03.014⟩. ⟨hal-00927582⟩

Partager

Métriques

Consultations de la notice

407