Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults.

Abstract : BACKGROUND: The development of optimal vaccination strategies for pneumococcal conjugate vaccines requires serotype-specific data on disease incidence and carriage prevalence. This information is lacking for the African meningitis belt. METHODS: We conducted hospital-based surveillance of acute bacterial meningitis in an urban and rural population of Burkina Faso during 2007-09. Cerebrospinal fluid was evaluated by polymerase chain reaction for species and serotype. In 2008, nasopharyngeal swabs were obtained from a representative population sample (1 month to 39 years; N = 519) and additional oropharyngeal swabs from 145 participants. Swabs were evaluated by culture. RESULTS: Annual pneumococcal meningitis incidence rates were highest among <6-month-old (58/100,000) and 15- to 19-year-old persons (15/100,000). Annual serotype 1 incidence was around 5/100,000 in all age groups. Pneumococcal carriage prevalence in nasopharyngeal swabs was 63% among <5-year-old children and 22% among ≥5-year-old persons, but adding oropharyngeal to nasopharyngeal swabs increased the estimated carriage prevalence by 60%. Serotype 1 showed high propensity for invasive disease, particularly among persons aged ≥5 years. CONCLUSIONS: Serotype 1 causes the majority of cases with a relatively constant age-specific incidence. Pneumococcal carriage is common in all age groups including adults. Vaccination programs in this region may need to include older target age groups for optimal impact on disease burden.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-unilim.archives-ouvertes.fr/hal-00933277
Contributeur : Elisabeth Grelier <>
Soumis le : lundi 20 janvier 2014 - 11:57:14
Dernière modification le : jeudi 11 juillet 2019 - 14:10:06

Lien texte intégral

Identifiants

Collections

Citation

Judith E Mueller, Seydou Yaro, Macaire S Ouédraogo, Natalia Levina, Berthe-Marie Njanpop-Lafourcade, et al.. Pneumococci in the African meningitis belt: meningitis incidence and carriage prevalence in children and adults.. PLoS ONE, Public Library of Science, 2012, 7 (12), pp.e52464. ⟨10.1371/journal.pone.0052464⟩. ⟨hal-00933277⟩

Partager

Métriques

Consultations de la notice

166