Photodynamic therapy can improve warts' discomfort in renal transplant patients prospective multicenter study.

Abstract : Many studies have been conducted showing that aminolevulinic acid (ALA)-photodynamic therapy (PDT) can be an alternative treatment for recalcitrant warts. Recently, we performed a study evaluating methyl-aminolevulinic acid (MAL)-PDT for the treatment of hand warts in a population of renal transplant patients. Two symmetrical targets were selected on each hand and randomly assigned to chemical keratolytic treatment followed by three cycles of ALA-PDT (75 J cm(-2) red light). Patients were evaluated after 3 months and a second run of PDT was performed if the total area and number of warts decreased less than 50%, with evaluation every 3 months for 1 year. Twenty patients were included and 16 were evaluable (9 M, 7 F). After 6 months the reduction of warts' area was 48.4% on the treated side versus 18.4% in the control area (P = 0.021). The decrease in the total number of warts was 41%versus 19.4% (P = NS). The global tolerance of the treatment was good with acceptable pain during irradiation. These results suggest that ALA-PDT is a safe and efficient treatment for transplanted patient warts. The improvement between treated and control zone is 20% due to the decrease in untreated warts' area and number.
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Soumis le : lundi 20 janvier 2014 - 16:37:32
Dernière modification le : mercredi 7 août 2019 - 14:36:25

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Agnès Sparsa, Sophie Blaise, Brigitte Tack, François Dalmay, Dominique Leroy, et al.. Photodynamic therapy can improve warts' discomfort in renal transplant patients prospective multicenter study.. Photochemistry and Photobiology, Wiley, 2012, 88 (4), pp.1023-6. ⟨10.1111/j.1751-1097.2012.01114.x⟩. ⟨hal-00933565⟩

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