Photodynamic therapy can improve warts' discomfort in renal transplant patients prospective multicenter study. - Université de Limoges Accéder directement au contenu
Article Dans Une Revue Photochemistry and Photobiology Année : 2012

Photodynamic therapy can improve warts' discomfort in renal transplant patients prospective multicenter study.

Résumé

Many studies have been conducted showing that aminolevulinic acid (ALA)-photodynamic therapy (PDT) can be an alternative treatment for recalcitrant warts. Recently, we performed a study evaluating methyl-aminolevulinic acid (MAL)-PDT for the treatment of hand warts in a population of renal transplant patients. Two symmetrical targets were selected on each hand and randomly assigned to chemical keratolytic treatment followed by three cycles of ALA-PDT (75 J cm(-2) red light). Patients were evaluated after 3 months and a second run of PDT was performed if the total area and number of warts decreased less than 50%, with evaluation every 3 months for 1 year. Twenty patients were included and 16 were evaluable (9 M, 7 F). After 6 months the reduction of warts' area was 48.4% on the treated side versus 18.4% in the control area (P = 0.021). The decrease in the total number of warts was 41%versus 19.4% (P = NS). The global tolerance of the treatment was good with acceptable pain during irradiation. These results suggest that ALA-PDT is a safe and efficient treatment for transplanted patient warts. The improvement between treated and control zone is 20% due to the decrease in untreated warts' area and number.

Dates et versions

hal-00933565 , version 1 (20-01-2014)

Identifiants

Citer

Agnès Sparsa, Sophie Blaise, Brigitte Tack, François Dalmay, Dominique Leroy, et al.. Photodynamic therapy can improve warts' discomfort in renal transplant patients prospective multicenter study.. Photochemistry and Photobiology, 2012, 88 (4), pp.1023-6. ⟨10.1111/j.1751-1097.2012.01114.x⟩. ⟨hal-00933565⟩
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