Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters.

Abstract : Neurocysticercosis (NC) is a parasitic disease caused by the infiltration of the larval stage of Taenia solium in the central nervous system. Clinical presentations are heterogeneous and particularly depend, on the age and gender of the host. We designed a clinical study to evaluate the hormonal changes associated with neurocysticercosis and the relationships between disease heterogeneity, endocrine and immunological status. A total of 50 patients and 22 healthy subjects were included. A precise clinical and radiological description of disease for each patient was recorded. A broad hormonal profile was assessed for each participant and, in a sub-group of patients, immunological features were also evaluated. Compared with controls, all patients had lower dehydroepiandrosterone (DHEA) concentration; male patients also had lower concentrations of 17β-estradiol and higher concentrations of luteinising hormone (LH). In the clinically severe patients, lower concentrations of progesterone and androstenedione were found in women. Higher concentrations of follicle stimulating hormone (FSH) and lower concentrations of testosterone were found in men when compared with the less clinically severe patients. Significant correlations were found between estradiol and IL-10 in male patients, and between dehydroepiandrosterone (DHEA) and IL-1β, and androstenedione and IL-17 in female patients. To our knowledge the present study constitutes the first demonstration that the presence of T. solium larvae in the central nervous system can modify the host environment by the induction of endocrine and immunological changes. These results provide a stimulating background to analyse the repercussions of these changes on the course of the disease and on patient reproductive health.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : Elisabeth Grelier Connectez-vous pour contacter le contributeur
Soumis le : jeudi 23 janvier 2014 - 14:42:21
Dernière modification le : mercredi 20 octobre 2021 - 01:31:11




Graciela Cárdenas, Ricardo Valdez, Brenda Sáenz, Oscar Bottasso, Gladis Fragoso, et al.. Impact of Taenia solium neurocysticercosis upon endocrine status and its relation with immuno-inflammatory parameters.. Int J Parasitol, 2012, 42 (2), pp.171-6. ⟨10.1016/j.ijpara.2011.11.009⟩. ⟨hal-00935401⟩



Les métriques sont temporairement indisponibles