Neurocysticercosis: local and systemic immune-inflammatory features related to severity.

Brenda Sáenz; Agnès Fleury; Anahí Chavarría; Marisela Hernández; José C Crispin; María I Vargas-Rojas; Gladis Fragoso; Edda Sciutto

Neurocysticercosis: local and systemic immune-inflammatory features related to severity.

Brenda Sáenz Agnès Fleury ¹ Anahí Chavarría Marisela Hernández José C Crispin María I Vargas-Rojas Gladis Fragoso Edda Sciutto ^*

* Auteur correspondant

1 Instituto Nacional de Neurologia y Neurocirugia

Abstract : Neurocysticercosis (NC) is caused by the establishment of Taenia solium cysticerci in the central nervous system. Previous studies have established that neuroinflammation plays a key role in the severity of the disease. However, the relationship between peripheral and local immune response remains inconclusive. This work studies the peripheral and local immune-inflammatory features and their relationships, toward the identification of potential peripheral immunologic features related to severity. A panel of cytokines was measured in paired cerebrospinal fluid (CSF) and in the supernatant of antigen-specific stimulated peripheral blood mononuclear cells samples (SN) in a total of 31 untreated inflammatory and non-inflammatory NC patients. Increased clinical and radiologic severity was associated with an increased cerebrospinal fluid cell count. A peripheral proliferative depression that negatively correlates with CSF cellularity and TNFα and that positively correlates with SN IL5 was observed in severe NC patients. These results provide evidences to support the systemic proliferative response as a biomarker to monitor the level of neuroinflammation, of possible value in the patients' follow-up during treatment.

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Santé publique et épidémiologie

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https://hal-unilim.archives-ouvertes.fr/hal-00935448
Contributeur : Elisabeth Grelier <>
Soumis le : jeudi 23 janvier 2014 - 15:16:40
Dernière modification le : samedi 24 septembre 2016 - 01:02:18

Neurocysticercosis: local and systemic immune-inflammatory features related to severity.

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Neurocysticercosis: local and systemic immune-inflammatory features related to severity.

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