Use Of SCO-Spondin Peptides For Inhibiting Or Preventing Neuronal Apoptosis Mediated By Cell Death Receptor Ligands

Abstract : The invention relates to a polypeptide derived from the TSR (thrombospondin type 1 units) of SCO-Spondin for inhibiting or preventing the apoptosis mediated by the cell death receptor ligands, such as TRAIL or FasL. The polypeptide of the invention comprises a sequence -W-S-A1-C-S-A2-C-G- wherein A1 and A2 are amino acid sequences comprising 1 to 5 amino acids. More particularly, the invention relates to said polypeptide for inhibiting or preventing the apoptosis associated with a disease selected from the group consisting of neurodegenerative disorders, cerebral ischemia, neuronal traumas, neuronal inflammatory diseases, and viral neurodegenerations.
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https://hal-unilim.archives-ouvertes.fr/hal-00938266
Contributeur : Philippe Sindou <>
Soumis le : mercredi 29 janvier 2014 - 11:37:54
Dernière modification le : jeudi 1 mars 2018 - 11:53:40

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  • HAL Id : hal-00938266, version 1

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Citation

Annie Meiniel. Use Of SCO-Spondin Peptides For Inhibiting Or Preventing Neuronal Apoptosis Mediated By Cell Death Receptor Ligands. Patent n° : US2011178023. 2011. ⟨hal-00938266⟩

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